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用于癌症荧光诊断与治疗的缺氧响应性纳米颗粒。

Hypoxia-responsive nanoparticles for fluorescence diagnosis and therapy of cancer.

作者信息

Zhang Yubing, Xing Jiaqi, Jiang Juan, Liao Maoliang, Pan Guojun, Wang Yanfeng

机构信息

State Key Laboratory of Advanced Drug Delivery and Release Systems, Key Laboratory for Biotechnology Drugs of National Health Commission, Key Laboratory of Rare and Rare Diseases in Shandong Province, School of Pharmacy (Institute of Pharmacy) of Shandong First Medical University, Jinan, Shandong 250117, China.

Shandong Luye Pharmaceutical Co., Ltd., China.

出版信息

Theranostics. 2025 Jan 1;15(4):1353-1375. doi: 10.7150/thno.104190. eCollection 2025.

DOI:10.7150/thno.104190
PMID:39816693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11729551/
Abstract

Hypoxia, caused by rapid tumor growth and insufficient oxygen supply, is a defining characteristic of numerous solid tumors and exerts a significant influence on tumor growth, metastasis, and invasion. Early diagnosis and effective killing of tumor cells are crucial for cancer treatment. In recent years, the emergence of nanomaterials has overcome the difficulties in the delivery of chemotherapeutic drugs and contrast agents to tumor area. In this review, we summarize the development of hypoxia-responsive nanoparticles for fluorescence imaging and tumor therapy in the last five years, and further discuss their design strategies and applications in bioimaging. In addition, we discuss the therapeutic strategies of hypoxia-responsive prodrugs on different nanoplatforms and the future prospects of hypoxia-responsive nanomedicine in tumor therapy.

摘要

由肿瘤快速生长和氧气供应不足引起的缺氧是众多实体瘤的一个决定性特征，对肿瘤的生长、转移和侵袭有重大影响。肿瘤细胞的早期诊断和有效杀伤对癌症治疗至关重要。近年来，纳米材料的出现克服了化疗药物和造影剂向肿瘤区域递送的困难。在这篇综述中，我们总结了过去五年中用于荧光成像和肿瘤治疗的缺氧响应性纳米颗粒的发展情况，并进一步讨论了它们的设计策略及其在生物成像中的应用。此外，我们还讨论了不同纳米平台上缺氧响应性前药的治疗策略以及缺氧响应性纳米药物在肿瘤治疗中的未来前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/cc18a3f08e67/thnov15p1353g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/4158cd8828c9/thnov15p1353g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/f2b6a9e8b0fb/thnov15p1353g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/05db596df196/thnov15p1353g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/f36d1b701b0e/thnov15p1353g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/0ffb094f8b6c/thnov15p1353g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/f1b08f0c2074/thnov15p1353g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/fa830b8a3389/thnov15p1353g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/e81775254f09/thnov15p1353g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/e4fcaa365f0b/thnov15p1353g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/cc18a3f08e67/thnov15p1353g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/4158cd8828c9/thnov15p1353g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/f2b6a9e8b0fb/thnov15p1353g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/05db596df196/thnov15p1353g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/f36d1b701b0e/thnov15p1353g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/0ffb094f8b6c/thnov15p1353g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/f1b08f0c2074/thnov15p1353g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/fa830b8a3389/thnov15p1353g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/e81775254f09/thnov15p1353g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/e4fcaa365f0b/thnov15p1353g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/11729551/cc18a3f08e67/thnov15p1353g010.jpg

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