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欧洲缺血性心脏病死亡率的性别差异。

Sex Disparities in Ischemic Heart Disease Mortality in Europe.

作者信息

Romeo Benedetta, Bergami Maria, Cenko Edina, Manfrini Olivia, Bugiardini Raffaele

机构信息

Laboratory of Epidemiological and Clinical Cardiology, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Sant'Orsola Hospital, Bologna, Italy.

出版信息

JACC Adv. 2024 Sep 2;3(12):101252. doi: 10.1016/j.jacadv.2024.101252. eCollection 2024 Dec.

DOI:10.1016/j.jacadv.2024.101252
PMID:39817073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11733970/
Abstract

BACKGROUND

Ischemic heart disease (IHD) is the leading cause of death in the European Union (EU). Understanding variations by sex, income, and countries can help in tailoring effective public health policies.

OBJECTIVES

The purpose of the study was to examine trends in sex differences in IHD prevalence and prognosis within the EU.

METHODS

We conducted a cross-sectional analysis of IHD using the Global Burden of Disease Study Database to examine trends in sex-specific age-standardized mortality rate (ASMR)-to-age-standardized prevalence rate (ASPR) ratio (ASMR-to-ASPR index) per 100,000 inhabitants/year across the EU from 2005 to 2019.

RESULTS

Men showed higher ASMR than women. However, the ASMR-to-ASPR index was notably higher in women than in men indicating that women who develop IHD have a higher risk of dying from the disease compared with their male counterparts. Despite a significant decline in ASMR across EU from 2005 to 2019 both among women (from 1.752 to 1.662) and men (from 3.372 to 3.135), sex disparities in ASMR-to-ASPR index (EU average: 4.96% vs 4.34%) persisted (with a women-to-men ratio ranging from 1.05 to 1.44). No significant relationship was found between country-specific ASMR or country income status and ASMR-to-ASPR index. Examples include Romania, which displayed higher ASMR (men: 219.87, women: 143.54) compared with Germany (men: 107.22, women: 60.76), yet with smaller differences in ASMR-to-ASPR index between women and men (Romania: 6.54% vs 5.85%; ratio: 1.12, and Germany: 4.79% vs 3.80%; ratio: 1.26).

CONCLUSIONS

Mortality from IHD has decreased substantially among EU countries. However, the declines were accompanied by a persistently higher ASMR-to-ASPR index in women, indicating significant potential for further gains in closing the gender gap in IHD mortality.

摘要

背景

缺血性心脏病（IHD）是欧盟（EU）的主要死因。了解性别、收入和国家之间的差异有助于制定有效的公共卫生政策。

目的

本研究的目的是调查欧盟内部缺血性心脏病患病率和预后的性别差异趋势。

方法

我们使用全球疾病负担研究数据库对缺血性心脏病进行了横断面分析，以研究2005年至2019年期间欧盟每10万居民/年按性别划分的年龄标准化死亡率（ASMR）与年龄标准化患病率（ASPR）之比（ASMR-ASPR指数）的趋势。

结果

男性的ASMR高于女性。然而，女性的ASMR-ASPR指数明显高于男性，这表明患缺血性心脏病的女性死于该病的风险高于男性。尽管2005年至2019年期间欧盟女性（从1.752降至1.662）和男性（从3.372降至3.135）的ASMR均显著下降，但ASMR-ASPR指数的性别差异（欧盟平均水平：4.96%对4.34%）仍然存在（女性与男性的比例在1.05至1.44之间）。未发现特定国家的ASMR或国家收入状况与ASMR-ASPR指数之间存在显著关系。例如，罗马尼亚的ASMR（男性：219.87，女性：143.54）高于德国（男性：107.22，女性：60.76），但女性与男性的ASMR-ASPR指数差异较小（罗马尼亚：6.54%对5.85%；比例：1.12，德国：4.79%对3.80%；比例：1.26）。

结论

欧盟国家缺血性心脏病死亡率已大幅下降。然而，下降的同时女性的ASMR-ASPR指数持续较高，这表明在缩小缺血性心脏病死亡率的性别差距方面仍有进一步改善的巨大潜力。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8db/11733970/a8e9e21f943c/gr2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8db/11733970/3de91a34a0e1/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8db/11733970/3e2ef53b2efb/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8db/11733970/57781fd65b4c/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8db/11733970/878668cecf96/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8db/11733970/49d22333a603/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8db/11733970/2d9be730572e/gr10.jpg
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