Kenner T, Moser M, Mohl W
J Biomech Eng. 1985 Feb;107(1):34-40. doi: 10.1115/1.3138517.
The mechanical oscillator technique permits determining blood density continuously with high accuracy. Using this technique arteriovenous density gradients were recorded in the coronary vascular bed of anesthetized dogs. It was found that the coronary sinus blood has a higher density than arterial blood due to the loss of filtered fluid in the microcirculation. The amount of fluid loss corresponds to the lymph flow in the myocardium. Increase of venous pressure leads to an increase of the density gradient. Intermittent coronary sinus occlusion (ICSO) surprisingly leads to a reduction of the density gradient. Injection of osmotically hypertensive fluids influences the arteriovenous gradient by shifting extravascular fluid into the blood. The method permits the determination of filtration coefficients and to estimate the tissue volume available for fluid exchange.
机械振荡器技术可高精度连续测定血液密度。利用该技术记录了麻醉犬冠状动脉床的动静脉密度梯度。结果发现，由于微循环中滤过液的流失，冠状窦血液的密度高于动脉血。液体流失量与心肌中的淋巴流量相对应。静脉压升高会导致密度梯度增加。令人惊讶的是，间歇性冠状窦闭塞（ICSO）会导致密度梯度降低。注射高渗液体通过将血管外液转移到血液中影响动静脉梯度。该方法可用于测定滤过系数，并估计可用于液体交换的组织体积。
