采用匹配的非亲缘供者和单倍型相合的亲缘供者进行的重型地中海贫血异基因造血干细胞移植。 - Suppr

Allogeneic hematopoietic stem cell transplantation for thalassemia major using matched unrelated donors and haploidentical related donors.

作者信息

Wang Feiyan, Qu Yuhua, Jiang Hua

机构信息

Department of Hematology and Oncology, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, Guangdong 510623, China.

出版信息

Chin Med J (Engl). 2025 Feb 20;138(4):490-492. doi: 10.1097/CM9.0000000000003465. Epub 2025 Jan 17.

DOI:10.1097/CM9.0000000000003465

PMID:39820187

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11845200/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d59/11845200/ca809080cfdb/cm9-138-490-g001.jpg

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Allogeneic hematopoietic stem cell transplantation for thalassemia major using matched unrelated donors and haploidentical related donors.采用匹配的非亲缘供者和单倍型相合的亲缘供者进行的重型地中海贫血异基因造血干细胞移植。

Chin Med J (Engl). 2025 Feb 20;138(4):490-492. doi: 10.1097/CM9.0000000000003465. Epub 2025 Jan 17.

Uniform Graft-versus-Host Disease Prophylaxis using Post-Transplantation Cyclophosphamide, Methotrexate, and Cyclosporine following Peripheral Blood Hematopoietic Stem Cell Transplantation from Matched and Haploidentical Donors for Transfusion-Dependent Thalassemia: A Retrospective Report from the Bone Marrow Failure Working Group of Hunan Province, China.使用移植后环磷酰胺、甲氨蝶呤和环孢素对匹配和单倍体相合供者外周血造血干细胞移植后输血依赖型地中海贫血进行统一的移植物抗宿主病预防：中国湖南省骨髓衰竭工作组的回顾性报告

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Comparison of matched sibling, unrelated and haploidentical donors in hematopoietic stem cell transplantation. A real-world experience from the Argentine Group for Bone Marrow Transplantation and Cell Therapy (GATMO-TC).造血干细胞移植中匹配同胞、无关和单倍体相合供者的比较。来自阿根廷骨髓移植与细胞治疗小组（GATMO-TC）的真实世界经验。

Medicina (B Aires). 2020;80(6):654-662.

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Haploidentical unrelated allogeneic stem cell transplantation for relapsed/refractory acute myeloid leukemia: a report on 1578 patients from the Acute Leukemia Working Party of the EBMT.亲缘半相合非亲缘异基因造血干细胞移植治疗复发/难治性急性髓系白血病：来自 EBMT 急性白血病工作组的 1578 例患者报告。

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Case report: First report of haploidentical allogeneic hematopoietic stem cell transplantation from donors with mild alpha-thalassemia for acute leukemia.病例报告：首例来自轻度α地中海贫血供者的单倍体相合异基因造血干细胞移植治疗急性白血病的报告

Front Oncol. 2022 Dec 8;12:986144. doi: 10.3389/fonc.2022.986144. eCollection 2022.

Outcomes of allogeneic haematopoietic stem cell transplantation from HLA-matched and alternative donors: a European Society for Blood and Marrow Transplantation registry retrospective analysis.来自HLA匹配供者和替代供者的异基因造血干细胞移植的结局：欧洲血液与骨髓移植学会登记处的回顾性分析

Lancet Haematol. 2019 Nov;6(11):e573-e584. doi: 10.1016/S2352-3026(19)30158-9. Epub 2019 Aug 30.

Transplantation for thalassemia major: alternative donors.重型地中海贫血的移植：替代供者

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Adv Exp Med Biol. 2017;1013:123-153. doi: 10.1007/978-1-4939-7299-9_5.

本文引用的文献

HLA-haploidentical vs matched unrelated donor transplants with posttransplant cyclophosphamide-based prophylaxis.HLA 单倍体相合与亲缘无关供者移植后应用环磷酰胺预防。

Blood. 2021 Jul 22;138(3):273-282. doi: 10.1182/blood.2021011281.

Successful mismatched hematopoietic stem cell transplantation for pediatric hemoglobinopathy by using ATG and post-transplant cyclophosphamide.成功地对儿科血红蛋白病患者进行了不匹配的造血干细胞移植，使用了 ATG 和移植后环磷酰胺。

Bone Marrow Transplant. 2021 Sep;56(9):2203-2211. doi: 10.1038/s41409-021-01302-0. Epub 2021 May 3.

Long-term results of the NF-08-TM protocol in stem cell transplant for patients with thalassemia major: A multi-center large-sample study.重型地中海贫血患者干细胞移植中NF-08-TM方案的长期结果：一项多中心大样本研究。

Am J Hematol. 2020 Nov;95(11):E297-E299. doi: 10.1002/ajh.25969. Epub 2020 Sep 17.

HLA-haploidentical hematopoietic stem cell transplantation in pediatric patients with hemoglobinopathies: current practice and new approaches.HLA 单倍体相合造血干细胞移植治疗儿童血液系统疾病：现状与新策略。

Bone Marrow Transplant. 2019 Aug;54(Suppl 2):743-748. doi: 10.1038/s41409-019-0598-x.

Vaccination of haemopoietic stem cell transplant recipients: guidelines of the 2017 European Conference on Infections in Leukaemia (ECIL 7).造血干细胞移植受者的疫苗接种：2017 年白血病感染的欧洲会议（ECIL 7）指南。

Lancet Infect Dis. 2019 Jun;19(6):e200-e212. doi: 10.1016/S1473-3099(18)30600-5. Epub 2019 Feb 8.

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Allogeneic hematopoietic stem cell transplantation for thalassemia major using matched unrelated donors and haploidentical related donors.

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