Albegger K
Laryngol Rhinol Otol (Stuttg). 1985 Feb;64(2):98-106.
The topical application of recently developed steroid aerosols is of great advantage in the treatment of rhinopathies. The modern steroid aerosols are inactivated after the first passage in the liver, following resorption by the respiratory or gastrointestinal mucosa. The desired therapeutic effect is therefore, restricted to the mucous membrane, and the well-known undesirable general side effects of the steroid hormone are avoided. The main indications for nasal application of steroid aerosols are allergic and non-allergic vasomotor rhinopathies and polyposis nasi. The basic requirement for a good therapeutic effect is tue proper application; therefore, satisfactory nasal ventilation and precise instruction and handling of the applicator are mandatory. The basic biochemical mechanisms of the glucocorticosteroid effects in relation to rhinopathies are given in a survey.
最近开发的类固醇气雾剂局部应用于鼻病治疗具有很大优势。现代类固醇气雾剂在经呼吸道或胃肠道黏膜吸收后，首次通过肝脏即被灭活。因此，预期的治疗效果仅限于黏膜，避免了类固醇激素众所周知的不良全身副作用。类固醇气雾剂鼻腔应用的主要适应证为变应性和非变应性血管运动性鼻病及鼻息肉病。良好治疗效果的基本要求是正确应用；因此，良好的鼻腔通气以及对使用者进行精确指导和操作是必不可少的。本文综述了糖皮质激素作用于鼻病的基本生化机制。
