Xavier-Santos Douglas, Bedani Raquel, de Almeida Vieira Isabel, Padilha Marina, Lima Clara Mariana Gonçalves, Silva Juliana Dara Rabêlo, Ferreira Beatriz Manfrinato, Giraldo Paulo César, Pagnossa Jorge Pamplona, Sivieri Katia, Antunes Adriane Elisabete Costa, Sant'Ana Anderson S
Department of Food Science and Nutrition, Faculty of Food Engineering, University of Campinas, Campinas, SP, Brazil.
Fraunhofer Institute for Process Engineering and Packaging (IVV), Freising, Germany.
Probiotics Antimicrob Proteins. 2025 Jan 17. doi: 10.1007/s12602-024-10444-8.
Women's health is related to several factors that include physical, mental, and reproductive health. Additionally, the vaginal microbiota modulation performs a fundamental role in the regulation of physiological homeostasis and dysbiosis, which provides us a potential overview of the use of different biotic agents and their implications for female health. The objective of this work was propitiated insights and conception about the influence of probiotics, prebiotics, synbiotics, and postbiotics as adjuvants for prevention/treatment on the main infections that can affect women's health. Therefore, seventy-one studies published in the Web of Science Core Collection database from 1999 to 2024 were evaluated and performed to a bibliometric analysis employing the VOSviewer software for scientific mapping and network analysis. Our results suggest that administration of biotic agents as adjuvants are relevant for the prevention and/or treatment of the main diseases that affect female health, since they contribute to a healthy vaginal microbiota through anti-inflammatory and antimicrobial activities. Most clinical studies have demonstrated the effectiveness of intervention using probiotics to the detriment of other biotic agents in women's health, being bacterial vaginosis, polycystic ovary syndrome, and vulvovaginal candidiasis, the main diseases evaluated. However, preclinical studies have emphasized that the inhibition of pathogens responsible for the process of vaginal dysbiosis may be due to the formation of biofilm and the synthesis of compounds that could prevent the adhesion of these microorganisms. Future perspectives point to the beneficial modulation of the vaginal microbiota by biotic agents as a promising adjuvant approach to improve women's health.
女性健康与多种因素相关，包括身体、心理和生殖健康。此外，阴道微生物群的调节在生理稳态和生态失调的调节中起着重要作用，这为我们提供了关于不同生物制剂的使用及其对女性健康影响的潜在概述。这项工作的目的是深入了解和认识益生菌、益生元、合生元和后生元作为预防/治疗佐剂对可能影响女性健康的主要感染的影响。因此，对1999年至2024年发表在科学网核心合集数据库中的71项研究进行了评估，并使用VOSviewer软件进行文献计量分析，以进行科学绘图和网络分析。我们的结果表明，使用生物制剂作为佐剂对预防和/或治疗影响女性健康的主要疾病具有重要意义，因为它们通过抗炎和抗菌活性有助于维持健康的阴道微生物群。大多数临床研究表明，在女性健康方面，使用益生菌进行干预比其他生物制剂更有效，细菌性阴道病、多囊卵巢综合征和外阴阴道念珠菌病是评估的主要疾病。然而，临床前研究强调，对导致阴道生态失调过程的病原体的抑制可能是由于生物膜的形成以及能够阻止这些微生物粘附的化合物的合成。未来的研究方向指出，生物制剂对阴道微生物群的有益调节是一种有前景的辅助方法，可改善女性健康。
