Cluster of Cancer Research Initiative IIUM (COCRII), International Islamic University Malaysia, 25200, Kuantan, Pahang, Malaysia.
Department of Biomedical Science, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, 25200, Kuantan, Pahang, Malaysia.
Probiotics Antimicrob Proteins. 2023 Oct;15(5):1298-1311. doi: 10.1007/s12602-022-09985-7. Epub 2022 Sep 1.
Oral carcinogenesis is preceded by oral diseases associated with inflammation such as periodontitis and oral candidiasis, which are contributed by chronic alcoholism, smoking, poor oral hygiene, and microbial infections. Dysbiosis is an imbalance of microbial composition due to oral infection, which has been reported to contribute to oral carcinogenesis. Therefore, in this review, we summarised the role of probiotics, prebiotics, synbiotics, and postbiotics in promoting a balanced oral microbiome, which may prevent oral carcinogenesis due to oral infections. Probiotics have been shown to produce biofilm, which possesses antibacterial activity against oral pathogens. Meanwhile, prebiotics can support growth and increase the benefit of probiotics. In addition, postbiotics possess antibacterial, anticariogenic, and anticancer properties that potentially aid in oral cancer prevention and treatment. The use of probiotics, prebiotics, synbiotics, and postbiotics for oral cancer management is still limited despite their vast potential, thus, discovering their prospects could herald a novel approach to disease prevention and treatment while participating in combating antimicrobial resistance.
口腔癌发生之前，口腔会先出现一些与炎症相关的疾病，例如牙周炎和口腔念珠菌病，这些疾病是由慢性酗酒、吸烟、口腔卫生不良和微生物感染引起的。微生态失调是由于口腔感染导致的微生物组成失衡，据报道，它会促进口腔癌的发生。因此，在这篇综述中，我们总结了益生菌、益生元、合生元和后生元在促进口腔微生物组平衡中的作用，这可能有助于预防由于口腔感染引起的口腔癌。益生菌已被证明能产生具有抗口腔病原体的抗菌活性的生物膜。同时，益生元可以支持益生菌的生长并增加其益处。此外，后生元具有抗菌、抗龋和抗癌特性，可能有助于预防和治疗口腔癌。尽管它们有很大的潜力，但益生菌、益生元、合生元和后生元在口腔癌管理中的应用仍然有限，因此，发现它们的前景可能预示着一种预防和治疗疾病的新方法，同时参与对抗抗菌药物耐药性。
