Korec Evžen, Ungrová Lenka, Kalvas Josef, Hejnar Jiří
ZOO Tábor a.s., Dukelských Hrdinů 19, 170 00 Prague 7, Czech Republic.
Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague 4, Czech Republic.
Vet Anim Sci. 2024 Dec 16;27:100420. doi: 10.1016/j.vas.2024.100420. eCollection 2025 Mar.
In the past years, dogs have served as a convenient natural model organism for longevity due to their similarity with humans concerning not only their environment but also the diseases and complications occurring in older age. Since many dog breeds have significantly shorter lifespan than their closely related breeds, identification of genes associated with longevity may help to elucidate its background and serve as a possible tool for selective breeding of long-living dogs. This genome-wide association study (GWAS) was undertaken to identify the candidate genes associated with longevity in Cavalier King Charles Spaniel individuals that have reached the age of more than 13 years. We described 15 SNPs localized in nine genes: like, and that are associated with longevity in purebred Cavalier King Charles Spaniels. These results are promising for future research and possible selective breeding of companion dogs with extended lifespan.
在过去的几年里，狗因其与人类不仅在环境方面，而且在老年时出现的疾病和并发症方面存在相似性，而成为研究长寿的一种方便的天然模式生物。由于许多犬种的寿命明显短于与其亲缘关系密切的犬种，鉴定与长寿相关的基因可能有助于阐明其背后的原因，并可能成为选择性培育长寿犬的一种工具。这项全基因组关联研究（GWAS）旨在鉴定在已达到13岁以上的查理士王小猎犬个体中与长寿相关的候选基因。我们描述了位于9个基因中的15个单核苷酸多态性（SNP），如、和，这些基因与纯种查理士王小猎犬的长寿相关。这些结果对于未来的研究以及对寿命延长的伴侣犬进行可能的选择性育种很有前景。
