Koller L D
Drug Chem Toxicol. 1979;2(1-2):99-110. doi: 10.3109/01480547908993184.
Environmental contaminants may alter one specific or several segments of the immune response. It is often necessary to examine each parameter (humoral, cell-mediated and macrophage) to assess the extent that each is involved. Lead and cadmium exposure results in suppression of many aspects of the immune response of animals. This suppression often occurs at very low subclinical dosages and therefore is detrimental to the health of animals and perhaps man by methods other than the typical well-documented toxicity which results at larger dosages. Methylmercury has been shown to inhibit the primary, secondary and memory immune response but few studies have described possible effects on T lymphocytes and macrophages. The effect that methylmercury imposes on the immune system needs further investigation.
环境污染物可能会改变免疫反应的一个特定部分或几个部分。通常有必要检查每个参数（体液免疫、细胞介导免疫和巨噬细胞免疫），以评估它们各自的参与程度。铅和镉暴露会导致动物免疫反应的许多方面受到抑制。这种抑制通常发生在非常低的亚临床剂量下，因此，除了在较大剂量下产生的典型的、有充分记录的毒性外，还会通过其他方式对动物乃至人类的健康造成损害。甲基汞已被证明会抑制初次免疫、二次免疫和记忆免疫反应，但很少有研究描述其对T淋巴细胞和巨噬细胞可能产生的影响。甲基汞对免疫系统的影响需要进一步研究。
