Koller L D, Roan J G
J Environ Pathol Toxicol. 1980 Nov;4(5-6):47-52.
The memory response of lymphocytes to antigen was altered in mice exposed to lead, cadmium, or methylmercury. Both lead (1300 ppm) and methylmercury(10 ppm) impaired the memory response while cadmium (300 ppm) stimulated memory. Memory was significantly affected only at the largest dosages where toxic signs were generally detected. The lower dosages did not affect the memory of lymphocytes which produce antibody. These data suggest that the T lymphocyte rather than the B lymphocyte is the cell affected when the secondary immune response is altered after exposure to subclinical amounts of these environmental contaminants.
暴露于铅、镉或甲基汞的小鼠中，淋巴细胞对抗原的记忆反应发生了改变。铅（1300 ppm）和甲基汞（10 ppm）均损害记忆反应，而镉（300 ppm）则刺激记忆。仅在通常检测到毒性迹象的最大剂量下，记忆才受到显著影响。较低剂量不影响产生抗体的淋巴细胞的记忆。这些数据表明，当暴露于亚临床剂量的这些环境污染物后二次免疫反应改变时，受影响的细胞是T淋巴细胞而非B淋巴细胞。
