Chang Nai-Wen, Kuo Chia-Hao, Chou Hung-Da, Chen Yi-Hsing
Department of Medical Education, Linkou main branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
BMC Ophthalmol. 2025 Jan 17;25(1):25. doi: 10.1186/s12886-025-03844-z.
While vaccination remains crucial in mitigating the impact of the COVID-19 pandemic, several ocular adverse events has been reported, including Acute Zonal Occult Outer Retinopathy (AZOOR) complex.
A 31-year-old female presented declined best corrected visual acuity (BCVA) and flashes in both eyes three days following second recombinant mRNA COVID-19 vaccine (Moderna). Fundus autofluorescence (FAF) illustrated speckled hyper-AF lesions surrounding right eye torpedo maculopathy site and hyper-AF lesions in the left macula. The spectral-domain optical coherence tomography delineated inner and outer segment (IS/OS) line disruption; hyperreflective deposits in the outer nuclear layer (ONL); and undetectable interdigitation zone (IDZ). Her BCVA further declined after 3-month observation, thus she received 8-month oral prednisolone and mycophenolate mofetil treatment. Her BCVA recovered; the hype-AF lesions resolved; and the IS/OS line and ONL resumed.
We present a rare case of AZOOR complex following COVID-19 vaccination inciting from torpedo retinopathy where outer-retinal barrier breaks down.
虽然疫苗接种对于减轻新冠疫情的影响仍然至关重要，但已报告了若干眼部不良事件，包括急性区域性隐匿性外层视网膜病变（AZOOR）综合征。
一名31岁女性在接种第二剂重组mRNA新冠疫苗（Moderna）三天后出现双眼最佳矫正视力（BCVA）下降和闪光感。眼底自发荧光（FAF）显示右眼鱼雷样黄斑病变部位周围有斑点状高自发荧光病变，左眼黄斑有高自发荧光病变。频域光学相干断层扫描显示内、外节（IS/OS）线中断；外核层（ONL）有高反射沉积物；且指状交叉区（IDZ）不可见。经过3个月的观察，她的BCVA进一步下降，因此接受了8个月的口服泼尼松龙和霉酚酸酯治疗。她的BCVA恢复；高自发荧光病变消退；IS/OS线和ONL恢复正常。
我们报告了一例新冠疫苗接种后罕见的由鱼雷样视网膜病变引发的AZOOR综合征病例，该病变导致视网膜外层屏障破坏。
