Saito Saho, Saito Wataru, Saito Michiyuki, Hashimoto Yuki, Mori Shohei, Noda Kousuke, Namba Kenichi, Ishida Susumu
Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan; Department of Ocular Circulation and Metabolism, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
PLoS One. 2015 Apr 28;10(4):e0125133. doi: 10.1371/journal.pone.0125133. eCollection 2015.
To evaluate the clinical features and investigate their relationship with visual function in Japanese patients with acute zonal occult outer retinopathy (AZOOR).
Fifty-two eyes of 38 Japanese AZOOR patients (31 female and 7 male patients; mean age at first visit, 35.0 years; median follow-up duration, 31 months) were retrospectively collected: 31 untreated eyes with good visual acuity and 21 systemic corticosteroid-treated eyes with progressive visual acuity loss. Variables affecting the logMAR values of best-corrected visual acuity (BCVA) and the mean deviation (MD) on Humphrey perimetry at initial and final visits were examined using multiple stepwise linear regression analysis.
In untreated eyes, the mean MD at the final visit was significantly higher than that at the initial visit (P = 0.00002). In corticosteroid-treated eyes, the logMAR BCVA and MD at the final visit were significantly better than the initial values (P = 0.007 and P = 0.02, respectively). The final logMAR BCVA was 0.0 or less in 85% of patients. Variables affecting initial visual function were moderate anterior vitreous cells, myopia severity, and a-wave amplitudes on electroretinography; factors affecting final visual function were the initial MD values, female sex, moderate anterior vitreous cells, and retinal atrophy.
Our data indicated that visual functions in enrolled patients significantly improved spontaneously or after systemic corticosteroids therapy, suggesting that Japanese patients with AZOOR have good visual outcomes during the follow-up period of this study. Furthermore, initial visual field defects, gender, anterior vitreous cells, and retinal atrophy affected final visual functions in these patients.
评估日本急性区域性隐匿性外层视网膜病变（AZOOR）患者的临床特征，并研究其与视功能的关系。
回顾性收集38例日本AZOOR患者的52只眼（31例女性和7例男性患者；初诊时平均年龄35.0岁；中位随访时间31个月）：31只未经治疗且视力良好的眼，以及21只接受全身皮质类固醇治疗且视力逐渐下降的眼。使用多元逐步线性回归分析检查影响初诊和末次随访时最佳矫正视力（BCVA）的logMAR值以及Humphrey视野检查平均偏差（MD）的变量。
在未经治疗的眼中，末次随访时的平均MD显著高于初诊时（P = 0.00002）。在接受皮质类固醇治疗的眼中，末次随访时的logMAR BCVA和MD显著优于初始值（分别为P = 0.007和P = 0.02）。85%的患者末次随访时logMAR BCVA为0.0或更低。影响初始视功能的变量为中度前玻璃体细胞、近视严重程度和视网膜电图a波振幅；影响最终视功能的因素为初始MD值、女性、中度前玻璃体细胞和视网膜萎缩。
我们的数据表明，入组患者的视功能在自发或全身皮质类固醇治疗后显著改善，这表明在本研究的随访期间，日本AZOOR患者具有良好的视力预后。此外，初始视野缺损、性别、前玻璃体细胞和视网膜萎缩影响这些患者的最终视功能。
