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本文引用的文献

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Evidence-based clinical practice guideline for the pharmacologic management of acute dental pain in adolescents, adults, and older adults: A report from the American Dental Association Science and Research Institute, the University of Pittsburgh, and the University of Pennsylvania.青少年、成年和老年人群急性牙痛的药物治疗循证临床实践指南:美国牙科协会科学研究所、匹兹堡大学和宾夕法尼亚大学的报告。
J Am Dent Assoc. 2024 Feb;155(2):102-117.e9. doi: 10.1016/j.adaj.2023.10.009.
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Adverse outcomes associated with opioid prescription by dentists in the Veterans Health Administration: A national cross-sectional study from 2015 to 2018.退伍军人事务部牙医开具阿片类药物处方的不良后果:2015 年至 2018 年的全国横断面研究。
J Public Health Dent. 2023 Jun;83(2):136-146. doi: 10.1111/jphd.12560. Epub 2023 Feb 17.
3
Can NSAIDs and Acetaminophen Effectively Replace Opioid Treatment Options for Acute Pain?非甾体抗炎药和对乙酰氨基酚能否有效替代阿片类药物治疗急性疼痛?
Expert Opin Pharmacother. 2021 Jun;22(9):1119-1126. doi: 10.1080/14656566.2021.1901885. Epub 2021 Jun 14.
4
Fatal acetaminophen poisoning with hepatic microvesicular steatosis in a child after repeated administration of therapeutic doses.儿童重复给予治疗剂量后发生致死性对乙酰氨基酚中毒伴肝微泡性脂肪变性。
Forensic Sci Int. 2020 May;310:110258. doi: 10.1016/j.forsciint.2020.110258. Epub 2020 Mar 17.
5
Restriction of non-opioid analgesics sold over-the-counter in Denmark: A national study of impact on poisonings.丹麦限制非处方销售的非阿片类镇痛药:一项关于中毒影响的全国性研究。
J Affect Disord. 2020 May 1;268:61-68. doi: 10.1016/j.jad.2020.02.043. Epub 2020 Feb 27.
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New Approaches to Pain Management.疼痛管理的新方法。
Dent Clin North Am. 2020 Apr;64(2):315-324. doi: 10.1016/j.cden.2019.12.001. Epub 2020 Jan 13.
7
Twenty-five-year follow-up of educational differences in toothache prevalence.二十五年来教育差异与牙痛患病率的关系。
Community Dent Oral Epidemiol. 2020 Apr;48(2):171-179. doi: 10.1111/cdoe.12516. Epub 2020 Jan 13.
8
Paracetamol Misuse and Dental Pain: Results from the French Observational DAntaLor Study.对乙酰氨基酚滥用与牙痛:法国 DAntaLor 观察性研究结果。
J Oral Facial Pain Headache. 2019;33(1):123-129. doi: 10.11607/ofph.1861.
9
Dental pain management - a cause of significant morbidity due to paracetamol overdose.牙痛管理——对乙酰氨基酚过量导致的严重发病原因。
Br Dent J. 2018 Apr 27;224(8):626-4. doi: 10.1038/sj.bdj.2018.264. Epub 2018 Apr 20.
10
Role of Dentists in Prescribing Opioid Analgesics and Antibiotics: An Overview.牙医在开具阿片类镇痛药和抗生素方面的作用:概述
Dent Clin North Am. 2018 Apr;62(2):279-294. doi: 10.1016/j.cden.2017.11.007.

牙科疼痛患者的镇痛药物过量。在两家牙科急诊诊所进行的横断面研究。

Analgesic Overdose in Patients With Dental Pain. A Cross-Sectional Study in Two Dental Emergency Clinics.

作者信息

Larsen Sofie Krahl, Markvart Merete, Søndenbroe Rasmus, Dalhoff Kim, Jensen Simon Storgård

机构信息

Department of Odontology, Section of Oral Biology and Immunopathology, University of Copenhagen, Copenhagen, Denmark.

Department of Odontology, Section of Clinical Oral Microbiology, University of Copenhagen, Copenhagen, Denmark.

出版信息

Basic Clin Pharmacol Toxicol. 2025 Feb;136(2):e14124. doi: 10.1111/bcpt.14124.

DOI:10.1111/bcpt.14124
PMID:39825523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11742470/
Abstract

Dental pain is common, and many patients use analgesics to alleviate the pain. Analgesics are readily accessible, and overdosing may lead to severe complications. This study explores the extent of analgesic overdosing in patients with dental pain. Data were collected from two dental emergency clinics in Copenhagen, Denmark, via questionnaires and interviews with 180 patients. Results showed that 82.8% (n = 149) had taken at least one type of analgesic, and 9% (n = 15) had exceeded the recommended maximum dosage. Of all patients with dental pain, 75.6% (n = 136) used paracetamol, 54.4% (n = 98) ibuprofen, 10% (n = 18) opioids, and 11.1% (n = 20) other types of analgesics. Most frequently, the pain was of pulpal origin (n = 119; 66.1%). Of all analgesics used, most were obtained places where guidance should be available, for example, pharmacies, dental clinics or hospitals (n = 152; 54%). The patients were aware of the recommended maximum daily dosage for paracetamol and ibuprofen in 39% (n = 70) and 41% (n = 73) of the cases, respectively. In conclusion, most patients with dental pain use analgesics to alleviate their pain. A substantial proportion of these patients overdose themselves, potentially putting them at risk of severe systemic complications. This study highlights the need for better patient education and safer pain management strategies.

摘要

牙痛很常见,许多患者使用镇痛药来缓解疼痛。镇痛药很容易获得,过量服用可能会导致严重并发症。本研究探讨了牙痛患者镇痛药过量服用的程度。通过对丹麦哥本哈根两家牙科急诊诊所的180名患者进行问卷调查和访谈收集数据。结果显示,82.8%(n = 149)的患者至少服用过一种镇痛药,9%(n = 15)的患者超过了推荐的最大剂量。在所有牙痛患者中,75.6%(n = 136)使用对乙酰氨基酚,54.4%(n = 98)使用布洛芬,10%(n = 18)使用阿片类药物,11.1%(n = 20)使用其他类型的镇痛药。最常见的是牙髓源性疼痛(n = 119;66.1%)。在所有使用的镇痛药中,大多数是在应该有指导的地方获得的,例如药店、牙科诊所或医院(n = 152;54%)。分别有39%(n = 70)和41%(n = 73)的患者知道对乙酰氨基酚和布洛芬的推荐最大日剂量。总之,大多数牙痛患者使用镇痛药来缓解疼痛。这些患者中有很大一部分过量服药,这可能使他们面临严重全身并发症的风险。本研究强调了加强患者教育和采用更安全的疼痛管理策略的必要性。