P2YR-IGFBP2信号传导：星形胶质细胞与神经元通讯的新因素
P2YR-IGFBP2 signaling: new contributor to astrocyte-neuron communication.
作者信息
Huang Dan, Tang Yong
机构信息
International Joint Research Centre On Purinergic Signalling, School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Acupuncture and Chronobiology Key Laboratory of Sichuan Province, School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
出版信息
Purinergic Signal. 2025 Jan 18. doi: 10.1007/s11302-025-10068-9.
In a recent article published in Nature Communications (Shigetomi et al Nat Commun 15(1):6525, 2024), Shigetomi et al. identified that upregulated astrocytic purinergic P2Y receptors (P2YR), acting via the downstream molecule, insulin-like growth factor binding protein 2 (IGFBP2), play a crucial role in neuronal hyperexcitability. In epilepsy and stroke models, P2YR-IGFBP2 signaling was found to mediate astrocyte-driven neuronal hyperexcitability and so is a new contributor to astrocyte-neuron communication. Thus, IGFBP2 could be an alternative target for treating the effects of upregulated P2YR activity in reactive astrocytes in neurological diseases.
在最近发表于《自然通讯》（重富等人，《自然通讯》15(1):6525，2024年）的一篇文章中，重富等人发现，上调的星形胶质细胞嘌呤能P2Y受体（P2YR）通过下游分子胰岛素样生长因子结合蛋白2（IGFBP2）发挥作用，在神经元过度兴奋中起关键作用。在癫痫和中风模型中，发现P2YR-IGFBP2信号传导介导星形胶质细胞驱动的神经元过度兴奋，因此是星形胶质细胞与神经元通讯的一个新因素。因此，IGFBP2可能是治疗神经疾病中反应性星形胶质细胞中P2YR活性上调影响的替代靶点。
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