成年大鼠皮下注射辣椒素后输尿管轴突损伤

Ureteral axon damage following subcutaneous administration of capsaicin in adult rats.

作者信息

Chung K, Schwen R J, Coggeshall R E

出版信息

Neurosci Lett. 1985 Jan 21;53(2):221-6. doi: 10.1016/0304-3940(85)90189-2.

Abstract

Systemic administration of capsaicin to adult rats results in the death of almost 90% of the axons in the ureter. Because of the massive axon loss we presume that sensory and possibly some sympathetic axons are killed. By contrast sensory axons in the dorsal root do not seem to be affected. We speculate that the axons in the ureter die because they are not protected by sleeves of perineurium. This hypothesis will be tested in subsequent work.

摘要

对成年大鼠进行辣椒素全身给药会导致输尿管中近90%的轴突死亡。由于大量轴突损失，我们推测感觉轴突以及可能的一些交感轴突被杀死。相比之下，背根中的感觉轴突似乎未受影响。我们推测输尿管中的轴突死亡是因为它们没有被神经束膜包裹保护。这一假设将在后续研究中进行验证。