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成年大鼠皮下注射辣椒素后输尿管轴突损伤

Ureteral axon damage following subcutaneous administration of capsaicin in adult rats.

作者信息

Chung K, Schwen R J, Coggeshall R E

出版信息

Neurosci Lett. 1985 Jan 21;53(2):221-6. doi: 10.1016/0304-3940(85)90189-2.

DOI:10.1016/0304-3940(85)90189-2
PMID:3982708
Abstract

Systemic administration of capsaicin to adult rats results in the death of almost 90% of the axons in the ureter. Because of the massive axon loss we presume that sensory and possibly some sympathetic axons are killed. By contrast sensory axons in the dorsal root do not seem to be affected. We speculate that the axons in the ureter die because they are not protected by sleeves of perineurium. This hypothesis will be tested in subsequent work.

摘要

对成年大鼠进行辣椒素全身给药会导致输尿管中近90%的轴突死亡。由于大量轴突损失,我们推测感觉轴突以及可能的一些交感轴突被杀死。相比之下,背根中的感觉轴突似乎未受影响。我们推测输尿管中的轴突死亡是因为它们没有被神经束膜包裹保护。这一假设将在后续研究中进行验证。

相似文献

1
Ureteral axon damage following subcutaneous administration of capsaicin in adult rats.成年大鼠皮下注射辣椒素后输尿管轴突损伤
Neurosci Lett. 1985 Jan 21;53(2):221-6. doi: 10.1016/0304-3940(85)90189-2.
2
Degeneration of axons in the ureteric and duodenal nerve plexuses of the adult rat following in vivo treatment with capsaicin.
Neurosci Lett. 1981 Aug 7;25(1):19-24. doi: 10.1016/0304-3940(81)90094-x.
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Selective degeneration by capsaicin of a subpopulation of primary sensory neurons in the adult rat.辣椒素对成年大鼠初级感觉神经元亚群的选择性退变作用
Neurosci Lett. 1985 Aug 30;59(2):209-14. doi: 10.1016/0304-3940(85)90201-0.
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Unmyelinated axon subpopulations in the rat peripheral nervous system.
Neurology. 1983 Jul;33(7):848-52. doi: 10.1212/wnl.33.7.848.
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Effect of capsaicin on neurites of cultured dorsal root ganglia and isolated neurons of chick embryos.
Neurosci Lett. 1987 Jan 27;73(3):237-41. doi: 10.1016/0304-3940(87)90251-5.
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A quantitative study of the effects of neonatal capsaicin treatment and of subsequent peripheral nerve transection in the adult rat.
Brain Res. 1986 Nov 5;397(1):130-6. doi: 10.1016/0006-8993(86)91376-4.
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The receptive part of the primary afferent axon is most vulnerable to systemic capsaicin in adult rats.在成年大鼠中,初级传入轴突的感受部分对全身应用辣椒素最为敏感。
Brain Res. 1990 Mar 19;511(2):222-6. doi: 10.1016/0006-8993(90)90165-8.
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Possible morphological correlates of capsaicin desensitization.辣椒素脱敏可能的形态学关联。
Brain Res. 1991 Feb 1;540(1-2):279-82. doi: 10.1016/0006-8993(91)90518-z.
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Capsaicin-induced neuronal degeneration: silver impregnation of cell bodies, axons, and terminals in the central nervous system of the adult rat.辣椒素诱导的神经元变性:成年大鼠中枢神经系统中细胞体、轴突和终末的银浸染
J Comp Neurol. 1988 May 1;271(1):79-90. doi: 10.1002/cne.902710109.
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Sensory innervation of the rat kidney and ureter as revealed by the anterograde transport of wheat germ agglutinin-horseradish peroxidase (WGA-HRP) from dorsal root ganglia.通过将小麦胚芽凝集素-辣根过氧化物酶(WGA-HRP)从背根神经节进行顺行运输所揭示的大鼠肾脏和输尿管的感觉神经支配。
J Comp Neurol. 1991 Sep 15;311(3):389-404. doi: 10.1002/cne.903110309.

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