脊髓性肌萎缩症患儿血清铜浓度与身体成分的关联：一项横断面研究
Association between serum copper concentration and body composition in children with spinal muscular atrophy: a cross-sectional study.
作者信息
Long Qi, Feng Yijie, Yu Yicheng, Chen Fei, Ma Ming, Mao Shanshan
机构信息
Department of Clinical Nutrition, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Department of Neurology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
出版信息
Asia Pac J Clin Nutr. 2025 Feb;34(1):84-90. doi: 10.6133/apjcn.202502_34(1).0008.
BACKGROUND AND OBJECTIVES
The role of serum copper in modulating body composition in patients with spinal muscular atrophy (SMA) remains uncertain. This study aimed to illustrate the correlation between serum copper concentration and body composition in children with SMA.
METHODS AND STUDY DESIGN
This study was conducted at a pediatric medical center in China from July 2019 to August 2022. The study included anthropometric measurements, serum analysis for copper, magnesium, zinc, and iron, as well as comprehensive body composition assessments. Multivariate analysis was utilized to assess the connection between serum copper concentration and body composition metrics.
RESULTS
This cross-sectional analysis included 87 patients [median (IQR) age: 7 years (5-10), 57.5% male] diagnosed with SMA receiving comprehensive multi-disciplinary management. The results revealed a positive association between serum copper concentration and both fat mass percentage (β = 0.50, 95% confidence interval (CI): 0.07 to 0.92, p = 0.025) and fat-muscle ratio (β = 0.02, 95% CI: 0.01 to 0.03, p = 0.009). Conversely, a negative correlation was found between serum copper concentration and muscle mass percentage (β = -0.70, 95% CI: -1.11 to -0.29, p = 0.001).
CONCLUSIONS
These findings suggest a correlation between copper concentration and body composition in SMA, offering valuable insights for addressing metabolic dysregulation in these patients.
背景与目的
血清铜在调节脊髓性肌萎缩症（SMA）患者身体成分方面的作用尚不确定。本研究旨在阐明SMA患儿血清铜浓度与身体成分之间的相关性。
方法与研究设计
本研究于2019年7月至2022年8月在中国一家儿科医疗中心进行。研究包括人体测量、血清铜、镁、锌和铁分析以及全面的身体成分评估。采用多变量分析来评估血清铜浓度与身体成分指标之间的联系。
结果
这项横断面分析纳入了87例诊断为SMA并接受综合多学科管理的患者[年龄中位数（四分位间距）：7岁（5 - 10岁），57.5%为男性]。结果显示血清铜浓度与脂肪量百分比（β = 0.50，95%置信区间（CI）：0.07至0.92，p = 0.025）和脂肪 - 肌肉比（β = 0.02，95% CI：0.01至0.03，p = 0.009）均呈正相关。相反，血清铜浓度与肌肉量百分比呈负相关（β = -0.70，95% CI：-1.11至-0.29，p = 0.001）。
结论
这些发现表明SMA患者的铜浓度与身体成分之间存在相关性，为解决这些患者的代谢失调提供了有价值的见解。
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