Xiong Wei, Liang Qinghan, Han Xiaojie, Cheng Qiaolu, Liu Qihang, Zuo Xifang, Wang Huiyu, He Huijing, Shan Guangliang
Department of Gynecology Endocrine & Reproductive Center, National Clinical Research Center for Obstetric & Gynecologic Diseases Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College/Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
Haidian District Women and Children's Hospital, Beijing, People's Republic of China.
Ann Med. 2025 Dec;57(1):2445183. doi: 10.1080/07853890.2024.2445183. Epub 2025 Jan 20.
Infertility has become a major global issue due to the trend of delaying marriage and advanced maternal age. Family/Birth cohort studies are essential for exploring ways to enhance health outcomes at both the individual and societal levels. However, there is a shortage of cohorts that include families who have utilized assisted reproductive technology (ART), particularly initiated at the early stages before pregnancy. The Assisted Reproductive Technology Cohort (APP-Cohort) is a prospective study aiming to investigate the epidemiology and risk factors of adverse gestational outcomes and other health issues in couples who have conceived through ART or naturally.
The cohort study's baseline survey commenced in January 2022 at several locations in Beijing, and enrollment is currently in progress. Both spouses filled out a questionnaire covering demographic, socio-economic, and various modifiable risk factors to gather information on their lifestyle. Physical examinations and biochemical tests were carried out, alongside regular yearly health check-ups throughout pregnancy and childhood. The survey data will be connected to electronic medical records to compile health information on the couples, newborns, and children.
The APP-Cohort study collected data from both wives and husbands before conception, allowing for early assessment of environmental risk factors for maternal and offspring health. With a focus on various types of risk factors such as genetic, environmental, and shared familial traits, the ongoing follow-up of this study will enable researchers to evaluate and distinguish the impacts of these factors on pregnancy outcomes, perinatal health, and children's health for individuals conceived naturally versus those conceived through ART. By utilizing practical experience and advanced mathematical analysis of the extensive data, the APP-Cohort study will provide valuable insights to promote the administration and success rate of ART in China.
由于晚婚趋势和产妇年龄增大，不孕症已成为一个重大的全球性问题。家庭/出生队列研究对于探索在个人和社会层面改善健康结果的方法至关重要。然而，缺乏包括使用辅助生殖技术（ART）的家庭的队列研究，尤其是在怀孕前早期就开始的研究。辅助生殖技术队列（APP-队列）是一项前瞻性研究，旨在调查通过ART或自然受孕的夫妇不良妊娠结局和其他健康问题的流行病学及风险因素。
该队列研究的基线调查于2022年1月在北京的几个地点开始，目前正在进行招募。夫妻双方都填写了一份涵盖人口统计学、社会经济和各种可改变风险因素的问卷，以收集他们生活方式的信息。进行了体格检查和生化检测，并在整个孕期和儿童期进行定期年度健康检查。调查数据将与电子病历相连接，以汇编有关夫妻、新生儿和儿童的健康信息。
APP-队列研究在受孕前收集了妻子和丈夫双方的数据，从而能够早期评估对孕产妇和后代健康的环境风险因素。该研究关注遗传、环境和共同家族特征等各种类型的风险因素，正在进行的随访将使研究人员能够评估和区分这些因素对自然受孕与通过ART受孕的个体的妊娠结局、围产期健康和儿童健康的影响。通过利用丰富数据的实践经验和先进的数学分析，APP-队列研究将为提高中国ART的管理水平和成功率提供有价值的见解。
