Department of Public Health, Laboratory for Mother and Child Health, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milan, Italy.
BMC Pediatr. 2022 Sep 15;22(1):548. doi: 10.1186/s12887-022-03599-2.
Knowing the research issues addressed by other cohorts when setting up new cohorts allows researchers to avoid unnecessary duplication of efforts, while permitting collaborations, including data merging data, to better tackle knowledge gaps. This study describes the topics addressed by European birth cohorts, the interaction between these cohort interests and aims, and describes the scientific publications deriving from the cohorts.
A previous study found 66 pregnancy and 45 birth cohorts in Europe. In this study, between August and October 2020, the predominant key areas addressed by the 45 birth cohorts identified in the previous study were evaluated, as were the publications found in PubMed that were associated with the 45 cohorts. A network analysis was performed to show the connections between the 13 key areas identified. A focus on a topic in common between two areas was provided, describing the related publications.
A total of 1512 references were found in PubMed (148 publications per cohort). Thirteen predominant key areas were identified, the most common of which was "Environmental" (addressed by 20 cohorts). The Environmental, Genes, and Lifestyle exposure areas were the prevalent topics characterizing the network figure. The Environmental area had the largest number of interactions with the other areas, while the Prematurity area (4 cohorts) the least. The focus provided on smoking led to the comparison of 35 publications from the Environmental group of cohorts and 22 from the Prematurity group, but their objectives did not overlap.
The results of this descriptive study show that the environment is a priority research area for cohorts in Europe and that cohorts with different research areas may have study issues in common, but may approach them from different viewpoints. Birth cohorts have wide-ranging aims and it would be almost impossible, and undesirable, to have perfectly overlapping and comparable objectives, but joining efforts would permit maximum use of available resources.
在建立新队列时了解其他队列所解决的研究问题可以使研究人员避免不必要的重复工作，同时允许进行合作，包括合并数据，以更好地解决知识空白。本研究描述了欧洲出生队列所解决的主题，这些队列利益和目标之间的相互作用，并描述了从中产生的科学出版物。
先前的一项研究发现了 66 项妊娠队列和 45 项出生队列。在这项研究中，在 2020 年 8 月至 10 月期间，评估了之前研究中确定的 45 项出生队列的主要重点领域，以及与 45 项队列相关的在 PubMed 中发现的出版物。进行了网络分析，以显示所确定的 13 个主要领域之间的联系。提供了两个领域之间的共同主题的重点，描述了相关的出版物。
在 PubMed 中发现了 1512 篇参考文献（每个队列 148 篇）。确定了 13 个主要的重点领域，其中最常见的是“环境”（有 20 个队列）。环境、基因和生活方式暴露领域是表征网络图的常见主题。环境领域与其他领域的互动最多，而早产领域（4 个队列）最少。关注吸烟导致比较了来自环境队列的 35 篇出版物和来自早产队列的 22 篇出版物，但它们的目标没有重叠。
这项描述性研究的结果表明，环境是欧洲队列的优先研究领域，具有不同研究领域的队列可能有共同的研究问题，但可能从不同的角度来解决这些问题。出生队列的目标范围广泛，要使目标完全重叠且可比几乎是不可能的，也是不可取的，但联合努力将允许最大限度地利用现有资源。
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