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豚鼠输精管中三磷酸腺苷诱导去极化过程中膜电导增加的证据。

Evidence for an increase in membrane conductance during adenosine triphosphate-induced depolarization in the guinea-pig vas deferens.

作者信息

Wakui M, Inomata H

出版信息

Pflugers Arch. 1985 Jan;403(1):112-4. doi: 10.1007/BF00583291.

DOI:10.1007/BF00583291
PMID:3982954
Abstract

The effects of exogenously applied adenosine triphosphate (ATP) on the smooth muscle of guinea-pig vas deferens were studied with the double sucrose-gap method. ATP evoked a membrane depolarization which was associated with a decrease in the size of electrotonic potentials. Conditioning hyperpolarization induced by current application caused an increase in the magnitude of the ATP-induced depolarization; the larger the conditioning hyperpolarization, the greater the ATP-induced depolarization. These results are discussed with respect to the ionic mechanism of the electrical event in response to ATP in this tissue.

摘要

采用双蔗糖间隙法研究了外源性三磷酸腺苷（ATP）对豚鼠输精管平滑肌的影响。ATP引起膜去极化，这与电紧张电位大小的降低有关。通过施加电流诱导的条件性超极化导致ATP诱导的去极化幅度增加；条件性超极化越大，ATP诱导的去极化就越大。针对该组织中ATP响应的电事件的离子机制对这些结果进行了讨论。

相似文献

1
Evidence for an increase in membrane conductance during adenosine triphosphate-induced depolarization in the guinea-pig vas deferens.豚鼠输精管中三磷酸腺苷诱导去极化过程中膜电导增加的证据。
Pflugers Arch. 1985 Jan;403(1):112-4. doi: 10.1007/BF00583291.
2
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引用本文的文献

1
Dual excitatory actions of acetylcholine at the neuromuscular junction in the guinea-pig vas deferens.乙酰胆碱在豚鼠输精管神经肌肉接头处的双重兴奋作用。
Pflugers Arch. 1986 Jun;406(6):587-93. doi: 10.1007/BF00584025.
2
A study of the post-tetanic twitch depression at the prostatic end of the rat vas deferens.大鼠输精管前列腺端强直后抽搐抑制的研究。
Pflugers Arch. 1987 May;408(6):628-33. doi: 10.1007/BF00581166.
3
An ATP-sensitive conductance in single smooth muscle cells from the rat vas deferens.大鼠输精管单个平滑肌细胞中的ATP敏感性电导。

本文引用的文献

1
Current spread in the smooth muscle of the guinea-pig vas deferens.豚鼠输精管平滑肌中的电流传播。
J Physiol. 1967 Mar;189(1):163-76. doi: 10.1113/jphysiol.1967.sp008161.
2
Electrical responses of smooth muscle cells of the mouse uterus to adenosine triphosphate.小鼠子宫平滑肌细胞对三磷酸腺苷的电反应。
J Physiol. 1983 Sep;342:499-515. doi: 10.1113/jphysiol.1983.sp014865.
3
The nature of non-cholinergic, non-adrenergic transmission in longitudinal and circular muscles of the guinea-pig ileum.豚鼠回肠纵肌和环肌中非胆碱能、非肾上腺素能传递的性质。
J Physiol. 1988 Jul;401:361-80. doi: 10.1113/jphysiol.1988.sp017167.
4
Adenosine triphosphate-activated inward current in isolated smooth muscle cells from rat vas deferens.大鼠输精管分离平滑肌细胞中的三磷酸腺苷激活内向电流。
Pflugers Arch. 1987 Aug;409(6):644-6. doi: 10.1007/BF00584668.
5
Contractile response and electrophysiological properties in enzymatically dispersed smooth muscle cells of rat vas deferens.
Pflugers Arch. 1987 Feb;408(2):112-9. doi: 10.1007/BF00581338.
6
Antagonism by nifedipine of contraction and Ca2(+)-influx evoked by ATP in guinea-pig urinary bladder.硝苯地平对豚鼠膀胱中由ATP诱发的收缩和Ca2+内流的拮抗作用。
Br J Pharmacol. 1990 Jun;100(2):370-4. doi: 10.1111/j.1476-5381.1990.tb15811.x.
J Physiol. 1982 Nov;332:375-91. doi: 10.1113/jphysiol.1982.sp014419.
4
Comparison of the effects of arylazido aminopropionyl ATP (ANAPP3), an ATP antagonist, on responses of the smooth muscle of the guinea-pig vas deferens to ATP and related nucleotides.ATP拮抗剂芳基叠氮基氨丙酰ATP（ANAPP3）对豚鼠输精管平滑肌对ATP及相关核苷酸反应的影响比较。
Eur J Pharmacol. 1982 Dec 3;85(3-4):277-90. doi: 10.1016/0014-2999(82)90215-1.
5
Pharmacological evidence that adenosine triphosphate and noradrenaline are co-transmitters in the guinea-pig vas deferens.三磷酸腺苷和去甲肾上腺素作为豚鼠输精管中共同递质的药理学证据。
J Physiol. 1984 Feb;347:561-80. doi: 10.1113/jphysiol.1984.sp015083.
6
Purinergic receptors: photoaffinity analog of adenosine triphosphate is a specific adenosine triphosphate antagonist.嘌呤能受体：三磷酸腺苷的光亲和类似物是一种特异性三磷酸腺苷拮抗剂。
Science. 1980 Jun 13;208(4449):1273-6. doi: 10.1126/science.6103581.
7
A comparison of the effects of adenosine triphosphate with noradrenaline and with the inhibitory potential of the guinea-pig taenia coli.三磷酸腺苷与去甲肾上腺素的作用及豚鼠结肠带抑制电位的比较。
J Physiol. 1973 May;231(1):167-77. doi: 10.1113/jphysiol.1973.sp010226.
8
The effect of intracellular current pulses in smooth muscle cells of the guinea pig vas deferens at rest and during transmission.豚鼠输精管平滑肌细胞静息时及传导过程中细胞内电流脉冲的作用。
J Gen Physiol. 1967 Nov;50(10):2459-75. doi: 10.1085/jgp.50.10.2459.