一项关于美国人群饮食炎症指数与青光眼患病率之间关联的横断面研究。

A cross-sectional study of the association between dietary inflammatory index and glaucoma prevalence in a US population.

作者信息

Chen Wen-Li, Zhang Li-Xia

机构信息

Department of Ophthalmology, Zhejiang Chinese Medical University Affiliated Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou 325000, Zhejiang Province, China.

Eye Hospital, China Academy of Chinese Medical Sciences, Beijing 100040, China.

出版信息

Int J Ophthalmol. 2025 Jan 18;18(1):139-145. doi: 10.18240/ijo.2025.01.17. eCollection 2025.

DOI:10.18240/ijo.2025.01.17

PMID:39829616

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11672095/

Abstract

AIM

To assess the relationship between dietary inflammatory index (DII) and prevalence of glaucoma among individuals aged 40y and above in the United States.

METHODS

Participants were drawn from 2 cycles of the National Health and Nutrition Examination Survey (NHANES, 2005-2008) for a cross-sectional study. DII was calculated from 24-hour dietary recall questionnaire conducted by experienced researchers and data analyzed in R according to the NHANES user guide, "Stratified Multi-stage Probability Sampling". The relationship between DII and glaucoma was evaluated by multi-factor logistic regression analysis and the existence of a non-linear association examined by restricted cubic spline (RCS) analysis.

RESULTS

A total of 5359 subjects were included and the cross-sectional analysis weighted to represent the US population of 109 million. DII was elevated in glaucoma patients (<0.001) and smoking and alcohol use contributed to significant differences (<0.001). DII correlated negatively with Healthy Eating Index (HEI)-2015 (Spearman rank correlation coefficient, =-0.49). RCS analysis showed a linear relationship between DII and glaucoma risk ( of non-linear relationship =0.575).

CONCLUSION

An increased DII is strongly associated with high risk of glaucoma and diet-induced inflammation should be controlled to delay glaucoma progression.

摘要

目的

评估美国40岁及以上人群的饮食炎症指数（DII）与青光眼患病率之间的关系。

方法

参与者来自两个周期的美国国家健康与营养检查调查（NHANES，2005 - 2008年），用于横断面研究。DII由经验丰富的研究人员通过24小时饮食回忆问卷计算得出，并根据NHANES用户指南“分层多阶段概率抽样”在R中进行数据分析。通过多因素逻辑回归分析评估DII与青光眼之间的关系，并通过受限立方样条（RCS）分析检查非线性关联的存在情况。

结果

共纳入5359名受试者，横断面分析加权后代表美国1.09亿人口。青光眼患者的DII升高（<0.001），吸烟和饮酒导致显著差异（<0.001）。DII与2015年健康饮食指数（HEI）呈负相关（斯皮尔曼等级相关系数，=-0.49）。RCS分析显示DII与青光眼风险之间存在线性关系（非线性关系的P = 0.575）。