O'Driscoll M, Crawford L, Biggar W D
Pediatr Infect Dis. 1985 Mar-Apr;4(2):137-41. doi: 10.1097/00006454-198503000-00005.
Clinical features and immune status have been studied in seven previously healthy children with disseminated staphylococcal disease. Six of seven patients had a history of a viral-type illness before developing disseminated staphylococcal disease. Five patients had a petechial rash. Endocarditis occurred in three patients, two of whom had a cerebral embolism. All seven patients had an abnormal urinary sediment, and in two it was suggestive of glomerulonephritis. Two had transient renal failure. Three patients had evidence of pneumonia, one of the three developed pneumatoceles and one developed a pleural effusion. Four had osteomyelitis and/or septic arthritis. All patients had a transient abnormality of intracellular bacterial killing by neutrophils. One patient died. Three patients have residual valvular heart disease; one of the three patients has weakness of one arm and another has a seizure disorder. Cellular and humoral immunity in all six surviving patients is normal. We speculate that an antecedent viral infection temporarily suppressed neutrophil function and predisposed these children to secondary and severe staphylococcal disease.
对7名先前健康的患有播散性葡萄球菌病的儿童的临床特征和免疫状态进行了研究。7名患者中有6名在发生播散性葡萄球菌病之前有病毒样疾病史。5名患者有瘀点皮疹。3名患者发生心内膜炎，其中2名有脑栓塞。所有7名患者尿沉渣均异常，其中2名提示肾小球肾炎。2名有短暂性肾衰竭。3名患者有肺炎证据，3名中的1名出现肺气囊，1名出现胸腔积液。4名有骨髓炎和/或化脓性关节炎。所有患者中性粒细胞对细胞内细菌的杀伤均有短暂异常。1名患者死亡。3名患者有残留瓣膜性心脏病；3名患者中的1名有一侧手臂无力，另1名有癫痫障碍。所有6名存活患者的细胞免疫和体液免疫均正常。我们推测先前的病毒感染暂时抑制了中性粒细胞功能，使这些儿童易患继发性严重葡萄球菌病。
