Wehbe Sarah, Firkins Stephen A, Sweeney Jacob R, Moore Halle C F, Rouphael Carol
Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH.
Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH.
ACG Case Rep J. 2025 Jan 17;12(1):e01582. doi: 10.14309/crj.0000000000001582. eCollection 2025 Jan.
Breast cancer (BC) is a common cancer in females. Spread to the gastrointestinal tract is rare. This is a 61-year-old woman with history of T2N0M0 lobular BC treated 5 years earlier. She underwent endoscopic evaluation for new-onset anemia and was found to have multiple gastric ulcers, a normal-appearing duodenum, and subtle colonic nodules. Targeted and random biopsies of abnormal and normal findings, respectively, showed adenocarcinoma with diffuse immunohistochemical staining compatible with her BC history. This highlights the importance of maintaining a high suspicion index in patients with lobular BC and the utility of random biopsies in such cases.
乳腺癌（BC）是女性常见的癌症。扩散至胃肠道较为罕见。这是一位61岁女性，5年前曾接受T2N0M0小叶型乳腺癌治疗。她因新发贫血接受内镜评估，发现有多处胃溃疡、外观正常的十二指肠以及细微的结肠结节。分别对异常和正常部位进行靶向活检及随机活检，结果显示为腺癌，免疫组化弥漫性染色与她的乳腺癌病史相符。这凸显了对小叶型乳腺癌患者保持高度怀疑指数的重要性，以及在此类病例中进行随机活检的作用。
