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一项单臂试点研究:用于预防精神病患者药物性体重增加的生活方式干预项目“更有意识地饮食”模块的开发与评估

Development and Evaluation of the "Eating More Consciously" Module of a Lifestyle Intervention Program to Prevent Medication-Induced Weight Gain in Psychiatric Patients: A One-Arm Pilot Study.

作者信息

Glocker Catherine, Simon Maria S, Adler Nicole, Eder Julia, Barton Barbara B, Musil Richard

机构信息

Department of Psychiatry und Psychotherapy, LMU Klinikum, München, Germany.

IFT Institut für Therapieforschung, Centre for Mental Health and Addiction Research, Munich, Germany.

出版信息

Alpha Psychiatry. 2024 Nov 1;25(6):737-745. doi: 10.5152/alphapsychiatry.2024.241718. eCollection 2024 Nov.


DOI:10.5152/alphapsychiatry.2024.241718
PMID:39830051
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11739912/
Abstract

OBJECTIVE: Overweight and obesity are health issues that are increasing worldwide. Patients with severe mental illness are particularly vulnerable for various reasons, including the intake of weight gain-associated drugs. In this pilot study, we targeted eating behavior as a predictor for medication-induced weight gain and developed a module of a prevention program ("Eating More Consciously") to be evaluated by psychiatric inpatients. METHODS: Thirty-three patients participated in a behaviorally oriented group therapy program with 2 modules of 120 minutes each and weekly follow-up measurements over 4 weeks. Measures included weight, laboratory parameters, the German versions of the Three-Factor Eating Questionnaire (Fragebogen Essverhalten; FEV) and the Food Craving Inventory (FCI) as well as a questionnaire on the implementation of the strategies in everyday life. RESULTS: Thirty-three participants completed both modules and felt that they had benefited from the module "Eating More Consciously". Fragebogen Essverhalten domain "cognitive restraint" scores increased significantly throughout the study ( = .039), and the FCI sum score decreased significantly ( = .003). CONCLUSION: We propose that the "Eating More Consciously" module is a promising approach to behavioral intervention in weight management in patients with severe mental illness. Prospective randomized controlled studies with a larger sample and a longer follow-up are needed.

摘要

目的:超重和肥胖是全球范围内日益严重的健康问题。患有严重精神疾病的患者由于各种原因,包括服用与体重增加相关的药物,特别容易受到影响。在这项试点研究中,我们将饮食行为作为药物引起体重增加的预测指标,并开发了一个预防计划模块(“更有意识地饮食”),供精神科住院患者评估。 方法:33名患者参加了一个以行为为导向的团体治疗项目,该项目有两个各120分钟的模块,并在4周内进行每周一次的随访测量。测量指标包括体重、实验室参数、德文版的三因素饮食问卷(Fragebogen Essverhalten;FEV)和食物渴望量表(FCI),以及一份关于日常生活中策略实施情况的问卷。 结果:33名参与者完成了两个模块,并认为他们从“更有意识地饮食”模块中受益。在整个研究过程中,Fragebogen Essverhalten领域的“认知抑制”得分显著增加(=0.039),FCI总分显著下降(=0.003)。 结论:我们认为,“更有意识地饮食”模块是对患有严重精神疾病的患者进行体重管理行为干预的一种有前景的方法。需要进行更大样本量和更长随访期的前瞻性随机对照研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64af/11739912/981a85774d40/ap-25-6-737_f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64af/11739912/2575172527ed/ap-25-6-737_f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64af/11739912/981a85774d40/ap-25-6-737_f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64af/11739912/2575172527ed/ap-25-6-737_f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64af/11739912/981a85774d40/ap-25-6-737_f002.jpg

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引用本文的文献

[1]
Who is at risk for weight gain after weight-gain associated treatment with antipsychotics, antidepressants, and mood stabilizers: A machine learning approach.

Acta Psychiatr Scand. 2025-3

本文引用的文献

[1]
Effectiveness of a Lifestyle Intervention for People With a Severe Mental Illness in Dutch Outpatient Mental Health Care: A Randomized Clinical Trial.

JAMA Psychiatry. 2023-9-1

[2]
Characterizing eating behavioral phenotypes in mood disorders: a narrative review.

Psychol Med. 2022-10

[3]
Lifestyle behaviors, metabolic disturbances, and weight gain in psychiatric inpatients treated with weight gain-associated medication.

Eur Arch Psychiatry Clin Neurosci. 2023-6

[4]
Time trends in pharmacological treatment of major depressive disorder: Results from the AMSP Pharmacovigilance Program from 2001-2017.

J Affect Disord. 2021-2-15

[5]
The Relationship Between Food Craving, Appetite-Related Hormones and Clinical Parameters in Bipolar Disorder.

Nutrients. 2020-12-29

[6]
Severe weight gain as an adverse drug reaction of psychotropics: Data from the AMSP project between 2001 and 2016.

Eur Neuropsychopharmacol. 2020-7

[7]
Update on weight-gain caused by antipsychotics: a systematic review and meta-analysis.

Expert Opin Drug Saf. 2020-3-12

[8]
Mindfulness-based emotional eating awareness training: taking the emotional out of eating.

Eat Weight Disord. 2020-6

[9]
A review of food craving measures.

Eat Behav. 2019-1

[10]
Obesity in Adolescents with Psychiatric Disorders.

Curr Psychiatry Rep. 2019-1-19

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