Centre for Neuroscience Studies (CNS), Queen's University, Kingston, ON, Canada.
Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
Psychol Med. 2022 Oct;52(14):2885-2898. doi: 10.1017/S0033291722002446. Epub 2022 Aug 25.
Mood disorders, including depressive and bipolar disorders, represent a multidimensional and prevalent group of psychiatric illnesses characterized by disturbances in emotion, cognition and metabolism. Maladaptive eating behaviors in mood disorders are diverse and warrant characterization in order to increase the precision of diagnostic criteria, identify subtypes and improve treatment strategies. The current narrative review synthesizes evidence for Eating Behavioral Phenotypes (EBP) in mood disorders as well as advancements in pathophysiological conceptual frameworks relevant to each phenotype. Phenotypes include maladaptive eating behaviors related to appetite, emotion, reward, impulsivity, diet style and circadian rhythm disruption. Potential treatment strategies for each phenotype are also discussed, including psychotherapeutic, pharmacological and nutritional interventions. Maladaptive eating behaviors related to mood disorders are relevant from both clinical and research perspectives, yet have been somewhat overlooked thus far. A better understanding of this aspect of mood disorders holds promise to improve clinical care in this patient group and contribute to the subtyping of these currently subjectively diagnosed and treated disorders.
心境障碍，包括抑郁障碍和双相障碍，是一组多维且普遍存在的精神疾病，其特征为情绪、认知和代谢紊乱。心境障碍中的适应不良的进食行为多种多样，值得进行特征描述，以提高诊断标准的准确性、识别亚型和改善治疗策略。目前的综述综合了心境障碍中进食行为表型（EBP）的证据，以及与每种表型相关的生理病理概念框架的进展。表型包括与食欲、情绪、奖励、冲动、饮食方式和昼夜节律紊乱相关的适应不良的进食行为。还讨论了每种表型的潜在治疗策略，包括心理治疗、药物治疗和营养干预。心境障碍相关的适应不良的进食行为无论从临床还是研究角度来看都很重要，但迄今为止一直被忽视。更好地理解心境障碍的这一方面有望改善这群患者的临床护理，并有助于对这些目前凭主观诊断和治疗的疾病进行亚型划分。
