Beech David J, Fagnen Charline, Kalli Antreas C
School of Medicine, University of Leeds, Leeds, LS2 9JT UK.
Leeds Institute of Cardiovascular and Metabolic Medicine, LIGHT Building, Clarendon Way, School of Medicine, University of Leeds, Leeds, LS2 9JT UK.
Biophys Rev. 2024 Oct 4;16(6):871-873. doi: 10.1007/s12551-024-01246-x. eCollection 2024 Dec.
The flow sensing endothelial cell lining of blood and lymphatic vessels is essential in vertebrates. While the mechanisms are still mysterious in many regards, several critical components became apparent through molecular biology studies. In this article, we focus on PIEZO1, which forms unusual force-sensing ion channels capable of rapid transduction of force into biological effect. We describe current knowledge and emerging challenges. We suggest the idea of using computation to construct the flow sensing mechanism of endothelium to advance understanding, develop testable hypotheses and potentially design novel therapeutic strategies and synthetic flow sensing devices.
血液和淋巴管的流量感应内皮细胞内衬在脊椎动物中至关重要。尽管在许多方面其机制仍很神秘，但通过分子生物学研究，一些关键成分已变得清晰。在本文中，我们重点关注PIEZO1，它形成了能够将力快速转化为生物学效应的异常力感应离子通道。我们描述了当前的知识和新出现的挑战。我们提出利用计算来构建内皮细胞的流量感应机制，以促进理解、提出可测试的假设，并有可能设计新的治疗策略和合成流量感应装置。
