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病例报告:FGF4L1反转录基因插入在长毛腊肠犬的高体型表型中不存在。

Case report: FGF4L1 retrogene insertion is lacking in the tall dachshund phenotype.

作者信息

Sullivan Stacey, Szeremeta Katarzyna Julia, Kutzler Michelle

机构信息

College of Veterinary Medicine, Auburn University, Auburn, AL, United States.

The International Working Teckel, Mannheim, Germany.

出版信息

Front Vet Sci. 2025 Jan 3;11:1522745. doi: 10.3389/fvets.2024.1522745. eCollection 2024.

Abstract

Two retrogene insertions, FGF4L1 (formerly 18-FGF4, colloquially CDPA) and FGF4L2 (formerly 12-FGF4, colloquially CDDY), have recently been discovered as determinants of short leg phenotype in dogs. This case study is comprised of a family of standard wirehaired dachshunds in which the dogs lacking the FGF4L1 gene exhibit a tall phenotype. The tall phenotype in the dachshunds of this report precludes the dog's working function of den work. The data presented in this report provide information as to how FGF4L1 status could be used in making breeding decisions in dachshunds to maintain working ability without compromising animal health.

摘要

最近发现了两个逆转录基因插入,即FGF4L1(以前称为18-FGF4,俗称CDPA)和FGF4L2(以前称为12-FGF4,俗称CDDY),它们是犬类短腿表型的决定因素。本案例研究由一个标准刚毛腊肠犬家族组成,其中缺乏FGF4L1基因的犬表现出高个表型。本报告中腊肠犬的高个表型妨碍了其挖掘工作的功能。本报告提供的数据说明了如何利用FGF4L1状态在腊肠犬的育种决策中保持工作能力而不损害动物健康。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0baa/11739356/411fe5ad8797/fvets-11-1522745-g001.jpg

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