Li Yixu, Liu Yifan, Xie Sujie, Zhu Yushu, Ding Xinran, Zhang Wei, Xian Shuyuan, Wu Guosheng, Sun Hanlin, Yan Jiale, Lu Bingnan, Yao Yuntao, Qian Weijin, Lu Yuwei, Yang Yiting, Xu Dayuan, Huang Runzhi, Ji Shizhao
Department of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, Shanghai, China.
Front Med (Lausanne). 2025 Jan 3;11:1451371. doi: 10.3389/fmed.2024.1451371. eCollection 2024.
Burns lead to systemic changes manifested by systemic disturbances in water-electrolyte balance and systemic metabolic and inflammatory responses. The hypermetabolic response after a burn injury relies on metabolic, hormonal, and inflammatory dysregulation mechanisms. This study aimed to provide a comprehensive bibliometric analysis of the burn metabolism research field, identifying key trends, influential contributors, and emerging research hotspots to inform future investigative efforts. Ultimately, we conducted an extensive review of the literature, synthesizing the findings to clarify the present understanding within our field of study.
We obtained 8,823 scientific publications on burn injury and metabolism from the core Web of Science (WOS) database collection. In this work, biblioshiny was used to visualize and analyze the data, and VOSviewer was used to verify the results.
From a total of 8,823 publications, we found a general upward trend in annual publications and citation frequency. According to Bradford's Law, 21 high-production journals were classified as core sources based on the number of publications, and the most productive journal was Burns. The most published countries and authors in this field were the United States and Herndon DN. The most local cited document in this field was the article titled "Catecholamines: Mediator of the Hypermetabolic Response to Thermal Injury" authored by Wilmore DW. The thematic map showed that studies on injury, thermal injury, and sepsis were relatively mature. In contrast, research on metabolism, stress, and responses, and research on mortality, resistance, and management were less well-developed but were essential for the field.
Research on burns and metabolism is increasing. Based on the bibliometric analysis, our study summarized the complex interplay between burn-induced systemic metabolic alterations and inflammatory responses, emphasizing the significance of hypermetabolism and its management. The role of propranolol, insulin, oxandrolone, and nutritional interventions in modulating the hypermetabolic state was discussed. Additionally, our study underscored the challenges of managing sepsis and drug-resistant infections in burn patients as an important future area of research.
烧伤会导致全身变化，表现为水电解质平衡的全身紊乱以及全身代谢和炎症反应。烧伤后的高代谢反应依赖于代谢、激素和炎症失调机制。本研究旨在对烧伤代谢研究领域进行全面的文献计量分析，确定关键趋势、有影响力的贡献者和新兴研究热点，为未来的研究工作提供参考。最终，我们对文献进行了广泛的综述，综合研究结果以阐明我们研究领域内的当前认识。
我们从科学引文索引（SCI）核心数据库中获取了8823篇关于烧伤与代谢的科学出版物。在这项工作中，使用biblioshiny对数据进行可视化和分析，并使用VOSviewer验证结果。
在总共8823篇出版物中，我们发现年度出版物数量和被引频次总体呈上升趋势。根据布拉德福定律，基于出版物数量将21种高产期刊归类为核心来源，其中发表文章最多的期刊是《烧伤》。该领域发表文章最多的国家和作者分别是美国和赫恩登·D·N。该领域被引用次数最多的国内文献是威尔莫尔·D·W撰写的题为《儿茶酚胺：热损伤高代谢反应的介质》的文章。主题图显示，关于损伤、热损伤和脓毒症的研究相对成熟。相比之下，关于代谢、应激和反应的研究以及关于死亡率、抵抗力和管理的研究虽发展程度较低，但对该领域至关重要。
烧伤与代谢的研究正在增加。基于文献计量分析，我们的研究总结了烧伤诱导的全身代谢改变与炎症反应之间的复杂相互作用，强调了高代谢及其管理的重要性。讨论了普萘洛尔、胰岛素、氧雄龙和营养干预在调节高代谢状态中的作用。此外，我们的研究强调了烧伤患者脓毒症和耐药感染管理方面的挑战，这是未来一个重要的研究领域。
