Wang Ying, Liu Tongtong, Liu Weijing, Zhao Hailing, Li Ping
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Front Pharmacol. 2024 Sep 3;15:1401939. doi: 10.3389/fphar.2024.1401939. eCollection 2024.
Disorders of lipid metabolism play a key role in the initiation and progression of chronic kidney disease (CKD). Recently, research on lipid metabolism in CKD has rapidly increased worldwide. However, comprehensive bibliometric analyses in this field are lacking. Therefore, this study aimed to evaluate publications in the field of lipid metabolism in CKD over the past 20 years based on bibliometric analysis methods to understand the important achievements, popular research topics, and emerging thematic trends.
Literature on lipid metabolism in CKD, published between 2004 and 2023, was retrieved from the Web of Science Core Collection. The VOSviewer (v.1.6.19), CiteSpace (v.6.3 R1), R language (v.4.3.2), and Bibliometrix (v.4.1.4) packages (https://www.bibliometrix.org) were used for the bibliometric analysis and visualization. Annual output, author, country, institution, journal, cited literature, co-cited literature, and keywords were also included. The citation frequency and H-index were used to evaluate quality and influence.
In total, 1,285 publications in the field of lipid metabolism in CKD were identified in this study. A total of 7,615 authors from 1,885 institutions in 69 countries and regions published articles in 466 journals. Among them, China was the most productive (368 articles), and the United States had the most citations (17,880 times) and the highest H-index (75). Vaziri Nosratola D, Levi Moshe, Fornoni Alessia, Zhao Yingyong, and Merscher Sandra emerged as core authors. Levi Moshe (2,247 times) and Vaziri Nosratola D (1,969 times) were also authors of the top two most cited publications. The International Journal of Molecular Sciences and Kidney International are the most published and cited journals in this field, respectively. Cardiovascular disease (CVD) and diabetic kidney disease (DKD) have attracted significant attention in the field of lipid metabolism. Oxidative stress, inflammation, insulin resistance, autophagy, and cell death are the key research topics in this field.
Through bibliometric analysis, the current status and global trends in lipid metabolism in CKD were demonstrated. CVD and DKD are closely associated with the lipid metabolism of patients with CKD. Future studies should focus on effective CKD treatments using lipid-lowering targets.
脂质代谢紊乱在慢性肾脏病（CKD）的发生和发展中起关键作用。近年来，全球范围内关于CKD脂质代谢的研究迅速增加。然而，该领域缺乏全面的文献计量分析。因此，本研究旨在基于文献计量分析方法评估过去20年CKD脂质代谢领域的出版物，以了解重要成果、热门研究主题和新兴主题趋势。
从科学网核心合集检索2004年至2023年发表的关于CKD脂质代谢的文献。使用VOSviewer（v.1.6.19）、CiteSpace（v.6.3 R1）、R语言（v.4.3.2）和Bibliometrix（v.4.1.4）软件包（https://www.bibliometrix.org）进行文献计量分析和可视化。还纳入了年发表量、作者、国家、机构、期刊、被引文献、共被引文献和关键词。使用被引频次和H指数评估质量和影响力。
本研究共识别出1285篇CKD脂质代谢领域的出版物。来自69个国家和地区1885个机构的7615名作者在466种期刊上发表了文章。其中，中国发表量最多（368篇），美国被引次数最多（17880次）且H指数最高（75）。Vaziri Nosratola D、Levi Moshe、Fornoni Alessia、Zhao Yingyong和Merscher Sandra成为核心作者。Levi Moshe（2247次）和Vaziri Nosratola D（1969次）也是被引次数最多的两篇出版物的作者。《国际分子科学杂志》和《肾脏病国际》分别是该领域发表量和被引次数最多的期刊。心血管疾病（CVD）和糖尿病肾病（DKD）在脂质代谢领域备受关注。氧化应激、炎症、胰岛素抵抗、自噬和细胞死亡是该领域的关键研究主题。
通过文献计量分析，展示了CKD脂质代谢的现状和全球趋势。CVD和DKD与CKD患者的脂质代谢密切相关。未来研究应聚焦于以降脂为靶点的有效CKD治疗方法。
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