Liu Yifan, Lu Bingnan, Yang Xinyue, Cui Jinming, Yang Tianyue, Zhang Haoyu, Zhao Zihui, Lyu Donghao, Li Yuanan, Yao Yuntao, Huang Runzhi, Pan Xiuwu
Department of Urology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China.
Ulink College of Shanghai, Shanghai, 201615, China.
Discov Oncol. 2025 May 26;16(1):928. doi: 10.1007/s12672-025-02750-6.
Kidney cancer is a worldwide prevalent urological malignancy and the leading cause of death. Sequencing and omics studies play a crucial role in unraveling its molecular mechanisms and diagnostic, prognostic, and therapeutic relevance. This study aims to offer a comprehensive review of the evolving trends and hotspots of sequencing and omics studies in kidney neoplasms.
We conducted the retrieval of scientific publications on sequencing and omics studies in kidney neoplasms from the Web of Science Core Collection (WoSCC) on July 3, 2023. The R-based bibliometrix package, VOSviewer, and CiteSpace were utilized to conduct the holistic bibliometric analysis to obtain objective and data-driven results. A comprehensive consultation of papers was then proceeded for an in-depth review.
Our investigation yielded a dataset containing 1260 records from 509 sources, with 43,404 references, from 1960 to 2023. Publication and citation frequencies have been consistently growing. In country analysis, China and the USA led the research, displaying substantial collaboration. Notable contributors like TEH BT, SAUTER G, and FUTREAL PA shaped this research landscape. Key journals such as PLoS One, Cancer Research, and New England Journal of Medicine actively participated in and significantly influenced this field. Distinguished publications and references were also revealed, along with their historical citation and co-citation relationships. A panel of keywords, including RCC, biomarker, and multi-omics data were identified and clustered.
We obtained a profound understanding of the developing trends and hotspots of research investigating sequencing and omics studies in kidney neoplasms. Specifically, we have highlighted three hotspots: "explore molecular mechanisms of RCC pathogenesis, progression, and metastasis", "identify molecular biomarkers of RCC for diagnosis, prognosis, and therapeutics", "investigate tumor heterogeneity and tailor personalized therapeutic strategies for RCC". Hopefully, our study will serve as a valuable reference for scientific researchers and clinical practitioners.
肾癌是一种在全球范围内流行的泌尿系统恶性肿瘤，也是主要的死亡原因。测序和组学研究在揭示其分子机制以及诊断、预后和治疗相关性方面发挥着关键作用。本研究旨在全面综述肾癌测序和组学研究的发展趋势与热点。
我们于2023年7月3日在科学网核心合集（WoSCC）上检索了关于肾癌测序和组学研究的科学出版物。利用基于R的文献计量软件包、VOSviewer和CiteSpace进行整体文献计量分析，以获得客观且基于数据的结果。随后对论文进行全面查阅以进行深入综述。
我们的调查产生了一个数据集，包含1960年至2023年期间来自509个来源的1260条记录，以及43404条参考文献。出版物和被引频次一直在持续增长。在国家分析中，中国和美国引领了该研究，展现出大量合作。像TEH BT、SAUTER G和FUTREAL PA等著名贡献者塑造了这一研究格局。《公共科学图书馆·综合》《癌症研究》和《新英格兰医学杂志》等关键期刊积极参与并显著影响了该领域。还揭示了杰出的出版物和参考文献及其历史引用和共引关系。确定并聚类了一组关键词，包括肾细胞癌、生物标志物和多组学数据。
我们对肾癌测序和组学研究的发展趋势与热点有了深入了解。具体而言，我们突出了三个热点：“探索肾细胞癌发病机制、进展和转移的分子机制”、“确定用于肾细胞癌诊断、预后和治疗的分子生物标志物”、“研究肿瘤异质性并为肾细胞癌量身定制个性化治疗策略”。希望我们的研究能为科研人员和临床医生提供有价值的参考。
