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择期与急诊非心脏手术后心脏并发症的发生率及预测因素

Incidence and Predictors of Cardiac Complications Following Elective Versus Urgent Non-cardiac Surgeries.

作者信息

Noor Shafqat, Rascón-Martínez Dulce M, Khoso Ashique Ali, Sharif Gul, Jamali Ayesha G, Ahmed Rizwan, Manzoor Hiba, Khalid Ayesha Akbar, Ali Algadi Halima Abd Alrahim

机构信息

General Surgery, Doctors Hospital Sahiwal, Sahiwal, PAK.

Anesthesia, Instituto Mexicano del Seguro Social (IMSS), Mexico City, MEX.

出版信息

Cureus. 2024 Dec 18;16(12):e75946. doi: 10.7759/cureus.75946. eCollection 2024 Dec.

Abstract

Cardiac complications following non-cardiac surgeries are a significant cause of perioperative morbidity and mortality. This meta-analysis aimed to assess the incidence and predictors of cardiac complications in patients undergoing elective and urgent non-cardiac surgeries. A comprehensive literature search was conducted in PubMed, Embase, and Cochrane Library databases for studies published between 2010 and 2024. Eligible studies evaluated cardiac outcomes such as myocardial infarction, arrhythmias, congestive heart failure, and cardiac arrest, reporting odds ratios (ORs) and confidence intervals (CIs) for associated risk factors. A total of seven studies were included, encompassing data from diverse populations and surgical settings. The pooled analysis revealed an overall incidence of cardiac complications of 2.8% (95% CI = 2.1%-3.5%) in elective surgeries and 5.4% (95% CI = 4.0%-6.8%) in urgent surgeries. Urgent procedures were associated with a significantly higher risk of cardiac events compared to elective surgeries (OR = 1.42, 95% CI = 1.15-1.76). Independent predictors of cardiac complications included advanced age, preoperative comorbidities such as hypertension and diabetes, reduced left ventricular ejection fraction, and elevated preoperative cardiac biomarkers, such as troponin levels. Significant heterogeneity was observed across studies, largely attributed to variations in surgical populations and definitions of cardiac outcomes. Subgroup analyses demonstrated that age >75 years (OR = 1.50, 95% CI = 1.20-1.90) and emergency procedures in patients with pre-existing cardiovascular disease (OR = 1.75, 95% CI = 1.30-2.10) were critical determinants of adverse outcomes. Additionally, intraoperative hypotension and prolonged surgical duration were associated with increased risk. The findings underscore the need for comprehensive preoperative risk assessment and tailored perioperative management strategies to mitigate cardiac risk, particularly in high-risk patients undergoing urgent surgeries. Enhanced utilization of preoperative biomarkers and risk scoring systems, coupled with vigilant intraoperative monitoring, may help reduce the burden of cardiac complications. While improvements in perioperative care have mitigated some risks, disparities remain, especially in resource-limited settings, warranting further research.

摘要

非心脏手术后的心脏并发症是围手术期发病和死亡的重要原因。这项荟萃分析旨在评估接受择期和急诊非心脏手术患者心脏并发症的发生率及预测因素。在PubMed、Embase和Cochrane图书馆数据库中对2010年至2024年发表的研究进行了全面的文献检索。符合条件的研究评估了心肌梗死、心律失常、充血性心力衰竭和心脏骤停等心脏结局,报告了相关危险因素的比值比(OR)和置信区间(CI)。共纳入七项研究,涵盖来自不同人群和手术环境的数据。汇总分析显示,择期手术中心脏并发症的总体发生率为2.8%(95%CI = 2.1%-3.5%),急诊手术中为5.4%(95%CI = 4.0%-6.8%)。与择期手术相比,急诊手术发生心脏事件的风险显著更高(OR = 1.42,95%CI = 1.15-1.76)。心脏并发症的独立预测因素包括高龄、术前合并症如高血压和糖尿病、左心室射血分数降低以及术前心脏生物标志物升高,如肌钙蛋白水平。各研究间观察到显著的异质性,主要归因于手术人群和心脏结局定义的差异。亚组分析表明,年龄>75岁(OR = 1.50,95%CI = 1.20-1.90)以及已有心血管疾病患者的急诊手术(OR = 1.75,95%CI = 1.30-2.10)是不良结局的关键决定因素。此外,术中低血压和手术时间延长与风险增加相关。研究结果强调需要进行全面的术前风险评估和制定针对性的围手术期管理策略以降低心脏风险,特别是在接受急诊手术的高危患者中。加强术前生物标志物和风险评分系统的应用,以及术中的密切监测,可能有助于减轻心脏并发症的负担。虽然围手术期护理的改善降低了一些风险,但差异仍然存在,尤其是在资源有限的环境中,这需要进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0094/11740829/2eb8cb4b1c63/cureus-0016-00000075946-i01.jpg

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