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一名患有艾滋病病毒和球孢子菌病的患者出现免疫重建炎症综合征诱导的血小板减少症。

Immune Reconstitution Inflammatory Syndrome-Induced Thrombocytopenia in a Patient With HIV and Coccidioidomycosis.

作者信息

Cheng Anthea, Lalehzarian Simon, Harimohan Hridya, Khamlong Melanie, Kim Stanley, Moosavi Leila

机构信息

Medical School, American University of the Caribbean, Cupecoy, SXM.

Internal Medicine, Kern Medical, Bakersfield, USA.

出版信息

Cureus. 2024 Dec 18;16(12):e75978. doi: 10.7759/cureus.75978. eCollection 2024 Dec.

DOI:10.7759/cureus.75978
PMID:39830540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11742094/
Abstract

Highly active antiretroviral therapy (HAART) is imperative in managing human immunodeficiency virus (HIV) infections. HAART aims to inhibit viral replication and improve immunity. Antiretroviral therapy has led to significant improvement in CD4-T cell counts and reductions in viral load, leading to improved overall immune function, increased survival, and decreased frequency of opportunistic infections. Immune reconstitution inflammatory syndrome (IRIS) is defined by a hyperinflammatory immune response within six months of initial treatment with HAART. It is caused by dysregulated inflammatory immune responses against pathogens. Herein, we discuss a rare presentation of IRIS-induced thrombocytopenia in a 20-year-old Hispanic male patient.

摘要

高效抗逆转录病毒疗法（HAART）对于治疗人类免疫缺陷病毒（HIV）感染至关重要。HAART旨在抑制病毒复制并提高免疫力。抗逆转录病毒疗法已使CD4-T细胞计数显著改善，病毒载量降低，从而改善了整体免疫功能、提高了生存率并减少了机会性感染的发生频率。免疫重建炎症综合征（IRIS）的定义是在开始使用HAART治疗的六个月内出现的一种高炎症性免疫反应。它是由针对病原体的炎症免疫反应失调引起的。在此，我们讨论一名20岁西班牙裔男性患者中IRIS诱导的血小板减少症的罕见表现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5328/11742094/3a6cf476f26d/cureus-0016-00000075978-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5328/11742094/3243955922ce/cureus-0016-00000075978-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5328/11742094/a91af344a4e0/cureus-0016-00000075978-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5328/11742094/34851eb00d0f/cureus-0016-00000075978-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5328/11742094/3a6cf476f26d/cureus-0016-00000075978-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5328/11742094/3243955922ce/cureus-0016-00000075978-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5328/11742094/a91af344a4e0/cureus-0016-00000075978-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5328/11742094/34851eb00d0f/cureus-0016-00000075978-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5328/11742094/3a6cf476f26d/cureus-0016-00000075978-i04.jpg

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本文引用的文献

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Immune Reconstitution Inflammatory Syndrome Associated Thrombocytopenia in a Patient with Human Immunodeficiency Virus Infection: A Rare Hematological Manifestation.一名人类免疫缺陷病毒感染患者中与免疫重建炎症综合征相关的血小板减少症：一种罕见的血液学表现。
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