Xu Ya-Xin, Niu Xiao-Xuan, Jia Wen-Chang, Wen Jing, Cheng Xue-Lin, Han Yan, Peng Ming-Hui, Zhou Jing, Liu Yao, Jiang Sun-Fang, Li Xiao-Pan
Department of Health Management Centre, Zhongshan Hospital, Fudan University, Shanghai 200030, China.
Department of General Practice, Zhongshan Hospital, Fudan University, Shanghai 200030, China.
World J Psychiatry. 2025 Jan 19;15(1):101750. doi: 10.5498/wjp.v15.i1.101750.
The burden of mental disorders (MD) in the Western Pacific Region (WPR) remains a critical public health concern, with substantial variations across demographics and countries.
To analyze the burden of MD in the WPR from 1990 to 2021, along with associated risk factors, to reveal changing trends and emerging challenges.
We used data from the Global Burden of Disease 2021, analyzing prevalence, incidence, and disability-adjusted life years (DALYs) of MD from 1990 to 2021. Statistical methods included age-standardisation and uncertainty analysis to address variations in population structure and data completeness.
Between 1990 and 2021, the prevalence of MD rose from 174.40 million cases [95% uncertainty interval (UI): 160.17-189.84] to 234.90 million cases (95%UI: 219.04-252.50), with corresponding DALYs increasing from 22.8 million (95%UI: 17.22-28.79) to 32.07 million (95%UI: 24.50-40.68). During this period, the burden of MD shifted towards older age groups. Depressive and anxiety disorders were predominant, with females showing higher DALYs for depressive and anxiety disorders, and males more affected by conduct disorders, attention-deficit hyperactivity disorder, and autism spectrum disorders. Australia, New Zealand, and Malaysia reported the highest burdens, whereas Vietnam, China, and Brunei Darussalam reported the lowest. Additionally, childhood sexual abuse and bullying, and intimate partner violence emerged as significant risk factors.
This study highlights the significant burden of MD in the WPR, with variations by age, gender, and nation. The coronavirus disease 2019 pandemic has exacerbated the situation, emphasizing the need for a coordinated response.
西太平洋地区（WPR）精神障碍（MD）的负担仍然是一个关键的公共卫生问题，在不同人口统计学特征和国家之间存在很大差异。
分析1990年至2021年西太平洋地区精神障碍的负担及其相关风险因素，以揭示变化趋势和新出现的挑战。
我们使用了《2021年全球疾病负担》的数据，分析了1990年至2021年精神障碍的患病率、发病率和伤残调整生命年（DALYs）。统计方法包括年龄标准化和不确定性分析，以应对人口结构和数据完整性的差异。
1990年至2021年期间，精神障碍的患病率从1.744亿例[95%不确定性区间（UI）：1.6017 - 1.8984亿例]上升至2.349亿例（95%UI：2.1904 - 2.5250亿例），相应的伤残调整生命年从2280万（95%UI：1722 - 2879万）增加到3207万（95%UI：245"0 - 4068万）。在此期间，精神障碍的负担向老年人群体转移。抑郁和焦虑障碍占主导地位，女性在抑郁和焦虑障碍方面的伤残调整生命年更高"，而男性受品行障碍、注意力缺陷多动障碍和自闭症谱系障碍的影响更大。澳大利亚、新西兰和马来西亚报告的负担最高，而越南、中国和文莱达鲁萨兰国报告的负担最低。此外，儿童期性虐待和欺凌以及亲密伴侣暴力成为重要的风险因素。
本研究突出了西太平洋地区精神障碍的重大负担，存在年龄、性别和国家差异。2019年冠状病毒病大流行加剧了这种情况，强调需要采取协调一致的应对措施。
