氧输送介质对离体大鼠肾脏的肾毒性作用。

Nephrotoxic effects of oxygen transport media in the isolated rat kidney.

作者信息

Millis R M, Barber J D, Anderson W A, Gold A J, Storm C B, Reindorf C A

出版信息

Proc Soc Exp Biol Med. 1985 Apr;178(4):643-7. doi: 10.3181/00379727-178-4-rc1.

Abstract

Perfusion of isolated kidneys from rats demonstrated the following nephrotoxic effects of Fluosol-DA: decreased glomerular filtration rate (GFR), urine flow rate (UFR), and fractional reabsorption of potassium (FrK+) (P less than 0.01). Fluosol-DA perfusions were at flow rates about equal to the physiologically normal rodent renal plasma flow rate of 4 ml/min. Stroma-free hemoglobin (SFH) perfusions, also at 4 ml/min, were associated with physiologically normal renal functions, as were those of control Krebs-Ringer bicarbonate (KRB) perfusions at 32 ml/min.

摘要

对大鼠离体肾脏进行灌注实验，结果显示氟碳乳剂-DA具有以下肾毒性作用：肾小球滤过率（GFR）、尿流率（UFR）以及钾离子重吸收分数（FrK+）降低（P<0.01）。氟碳乳剂-DA的灌注流速约等于啮齿动物生理正常肾血浆流速4 ml/min。无基质血红蛋白（SFH）的灌注流速同样为4 ml/min，其肾脏功能保持生理正常，流速为32 ml/min的对照 Krebs-Ringer 碳酸氢盐（KRB）灌注也是如此。