Villalba-Davila Priscila, Aronson Stephanie, Lat Jessica, Charles Cassandra, Schroeder Bryce, Pittman Meredith, Tang Vivian, Wallach Thomas
Department of Pediatrics, SUNY Downstate Health Sciences University, Brooklyn, New York, USA.
Department of Pediatrics, Maimonides Medical Center, Brooklyn, New York, USA.
J Pediatr Gastroenterol Nutr. 2025 Apr;80(4):617-622. doi: 10.1002/jpn3.12464. Epub 2025 Jan 20.
Fecal calprotectin (FC) is a marker commonly used in the diagnosis and follow-up of inflammatory bowel diseases (IBD). However, other gastrointestinal conditions, like H. pylori (HP) infection, can result in increased neutrophil activity as well. We set out to assess the impact of HP infection on FC and downstream gastrointestinal care via a retrospective study.
In this study, we collected data from two institutions in Brooklyn, NY, in a high immigrant density community. We reviewed data from patients who underwent esophagogastroduodenoscopy (EGD) between January 2017 and October 2022. Patients aged 6-18 years old with an FC level 6 months prior to EGD and HP testing were included.
Of 129 patients, 37 (28.7%) tested positive for HP infection. The mean FC level was significantly elevated in HP-positive patients (241.2, confidence interval [CI]: 161.0-321.3) as compared with HP-negative patients (88.1, CI: 59.1-117.0) (p < 0.001). Patients with higher FC levels were also more likely to undergo colonoscopies (p = 0.003).
HP infection is associated with increased calprotectin, and calprotectin increases in HP patients are associated with an increased risk of colonoscopy.
粪便钙卫蛋白（FC）是常用于炎症性肠病（IBD）诊断和随访的标志物。然而，其他胃肠道疾病，如幽门螺杆菌（HP）感染，也会导致中性粒细胞活性增加。我们通过一项回顾性研究来评估HP感染对FC及下游胃肠道护理的影响。
在本研究中，我们收集了纽约布鲁克林两个机构的数据，该社区移民密度高。我们回顾了2017年1月至2022年10月期间接受食管胃十二指肠镜检查（EGD）的患者数据。纳入在EGD和HP检测前6个月FC水平的6至18岁患者。
129例患者中，37例（28.7%）HP感染检测呈阳性。与HP阴性患者（88.1，置信区间[CI]：59.1 - 117.0）相比，HP阳性患者的平均FC水平显著升高（241.2，CI：161.0 - 321.3）（p < 0.001）。FC水平较高的患者也更有可能接受结肠镜检查（p = 0.003）。
HP感染与钙卫蛋白增加有关，HP患者钙卫蛋白增加与结肠镜检查风险增加有关。
