用于近红外成像的硅罗丹明1,2 - 二氧杂环丁烷化学发光体
A silicon rhodamine 1,2-dioxetane chemiluminophore for near-infrared imaging.
作者信息
Osman Rokia, Haris Uroob, Cabello Maidileyvis C, Mason Ralph P, Lippert Alexander R
机构信息
Department of Chemistry, Southern Methodist University, Dallas, TX 75275-0314, USA.
Prognostic Imaging Research Laboratory, Pre-clinical Imaging Section, Department of Radiology, UT Southwestern Medical Center, Dallas, TX 75390-9058, USA.
出版信息
Org Biomol Chem. 2025 Feb 19;23(8):1846-1850. doi: 10.1039/d4ob02002b.
Near-infrared (NIR) chemiluminescent probes have attracted increasing attention in recent years due to their attractive properties for imaging. Herein, we developed a NIR chemiluminophore silicon rhodamine (SiRCL-1) based on the intramolecular energy transfer process from excited state benzoate to a silicon rhodamine emitter under aqueous conditions. SiRCL-1 exhibited dual emission peaks at 540 nm and 680 nm with a high signal penetration through tissue at 680 nm (>30 mm) and long-lasting luminescence (>50 min), demonstrating its significance as a chemiluminescence scaffold for biological application.
近年来，近红外（NIR）化学发光探针因其在成像方面的诱人特性而受到越来越多的关注。在此，我们基于分子内从激发态苯甲酸酯到硅罗丹明发射体在水性条件下的能量转移过程，开发了一种近红外化学发光团硅罗丹明（SiRCL-1）。SiRCL-1在540 nm和680 nm处表现出双重发射峰，在680 nm处具有高信号组织穿透性（>30 mm）和持久发光（>50分钟），证明了其作为生物应用化学发光支架的重要性。
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