基于硅罗丹明的近红外荧光探针用于谷氨酰转移酶。
Silicon Rhodamine-Based Near-Infrared Fluorescent Probe for γ-Glutamyltransferase.
机构信息
PRESTO, Japan Science and Technology Agency (JST) , 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.
AMED CREST, Japan Agency for Medical Research and Development , 1-7-1 Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan.
出版信息
Bioconjug Chem. 2018 Feb 21;29(2):241-244. doi: 10.1021/acs.bioconjchem.7b00776. Epub 2018 Jan 19.
We designed and synthesized an activatable near-infrared (NIR) fluorescent probe for γ-glutamyltransferase, based on an asymmetric silicon rhodamine scaffold with an optimized equilibrium of intramolecular spirocyclization. The synthesized probe exhibits dramatic NIR fluorescence activation and, in combination with previously reported probes, enables discrimination of tumors with different enzymatic profiles.
我们设计并合成了一种基于不对称硅罗丹明骨架的可激活的近红外（NIR）荧光探针γ-谷氨酰转移酶，该探针具有优化的分子内螺环化平衡。合成的探针表现出显著的 NIR 荧光激活，并与之前报道的探针相结合，能够区分具有不同酶谱的肿瘤。
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