Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China.
Chem Commun (Camb). 2020 Feb 25;56(16):2455-2458. doi: 10.1039/c9cc09666c.
A group of asymmetric Si-rhodamine scaffolds was designed for protease-activated NIR probes. Dual pH-inertia for both spirocyclized fluorescent probes and fluorescent products of zwitterions form over a wide range of pH (4.0-11.0). Leucine aminopeptidase (LAP) and γ-glutamyl transpeptidase (GGT) were monitored by fluorescent imaging in vivo.
一组不对称的硅罗丹明支架被设计用于蛋白酶激活的近红外探针。两种螺环化荧光探针和两性离子荧光产物在很宽的 pH 范围内（4.0-11.0）都具有双重 pH 惰性。亮氨酸氨基肽酶（LAP）和 γ-谷氨酰转肽酶（GGT）可通过体内荧光成像进行监测。
