不对称硅罗丹明支架：体内耐 pH 变化的蛋白酶激活型近红外探针的合理设计。
Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes in vivo.
机构信息
Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China.
出版信息
Chem Commun (Camb). 2020 Feb 25;56(16):2455-2458. doi: 10.1039/c9cc09666c.
PMID:31996872
Abstract
A group of asymmetric Si-rhodamine scaffolds was designed for protease-activated NIR probes. Dual pH-inertia for both spirocyclized fluorescent probes and fluorescent products of zwitterions form over a wide range of pH (4.0-11.0). Leucine aminopeptidase (LAP) and γ-glutamyl transpeptidase (GGT) were monitored by fluorescent imaging in vivo.
摘要
一组不对称的硅罗丹明支架被设计用于蛋白酶激活的近红外探针。两种螺环化荧光探针和两性离子荧光产物在很宽的 pH 范围内（4.0-11.0）都具有双重 pH 惰性。亮氨酸氨基肽酶（LAP）和 γ-谷氨酰转肽酶（GGT）可通过体内荧光成像进行监测。
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