Seehafer Svea, Schmill Lars-Patrick, Peters Sönke, Jansen Olav, Aludin Schekeb
Department of Radiology and Neuroradiology, University Hospital of Schleswig-Holstein, Arnold-Heller-Str. 3, Hs D (Neurozentrum), 24105, Kiel, Germany.
Clin Neuroradiol. 2025 Jan 20. doi: 10.1007/s00062-024-01489-x.
Magnetic Resonance Imaging based brain segmentation and volumetry has become an important tool in clinical routine and research. However the impact of the used hardware is only barely investigated. This study aims to assess the influence of scanner manufacturer, field strength and head-coil on volumetry results.
10 healthy subjects (27.4 ± 1.71 years) were prospectively examined in a Philips Achieva 1.5T, Philips Ingenia CX 3T, Siemens MAGNETOM Aera 1.5T and Siemens MAGNETOM Vida 3T, the latter equipped with three different head coils, within one day. Brain volumetry of the whole brain, total white and grey matter, the cortical grey matter of the supratentorial lobes as well as regions important for the differentiation of neurodegenerative diseases of the dementia and movement disorder spectrum and the ventricular system was performed using the CE-certified software mdbrain by mediaire (Berlin, Germany). Both raw volumetry results and percentile allocation provided by the software were analysed.
This study reveals significantly different volumetry results for all examined brain regions beside the ventricular system between the different MRI devices but comparable results between the different head coils. When examining the percentile allocation provided by used software, the Intraclass-Correlation-Coefficient (ICC) values were even lower than the raw volume ICC values ranging from poor to excellent correlation.
The present study reveals highly relevant results that need to be considered both in clinical routine when analysing follow-up examinations from different scanner types and clinical research, especially when planning longitudinal and/or multicentre studies.
基于磁共振成像的脑部分割和容积测量已成为临床常规和研究中的重要工具。然而，所用硬件的影响却鲜有研究。本研究旨在评估扫描仪制造商、场强和头部线圈对容积测量结果的影响。
10名健康受试者（27.4 ± 1.71岁）在一天内分别接受了飞利浦Achieva 1.5T、飞利浦Ingenia CX 3T、西门子MAGNETOM Aera 1.5T和西门子MAGNETOM Vida 3T的检查，后者配备了三种不同的头部线圈。使用德国柏林mediaire公司的CE认证软件mdbrain对全脑、总白质和灰质、幕上叶的皮质灰质以及对痴呆和运动障碍谱系神经退行性疾病鉴别重要的区域和脑室系统进行脑容积测量。对软件提供的原始容积测量结果和百分位数分配进行了分析。
本研究显示，不同MRI设备之间，除脑室系统外，所有检查脑区的容积测量结果存在显著差异，但不同头部线圈之间的结果具有可比性。在检查所用软件提供的百分位数分配时，组内相关系数（ICC）值甚至低于原始容积ICC值，相关性从差到优不等。
本研究揭示了高度相关的结果，在分析来自不同扫描仪类型的随访检查时，临床常规以及临床研究中都需要考虑这些结果，尤其是在规划纵向和/或多中心研究时。
