Oyovwi Mega Obukohwo, Ogenma Ugushida Thankgod, Onyenweny Anthonia
Department of Physiology, Faculty of Basic Medical Sciences, Adeleke University, Ede, Osun State, Nigeria.
Department of Public Health, Faculty of Basic Medical Sciences, Adeleke University, Ede, Osun State, Nigeria.
Mol Biol Rep. 2025 Jan 20;52(1):140. doi: 10.1007/s11033-025-10248-1.
This review investigates the intricate relationship between exercise, brain-derived neurotrophic factor (BDNF), neuroplasticity, and cognitive function, with a focus on implications for neuropsychiatric and neurodegenerative disorders. A systematic review was conducted by searching various databases for relevant studies that explored the connections between exercise, BDNF, neuroplasticity, and cognitive health. The analysis of eligible studies revealed that exercise increases BDNF levels in the brain, promoting neuroplasticity and enhancing cognitive functions. Furthermore, we discuss the protective effects of exercise against cognitive decline and neurological disorders, suggesting that BDNF plays a critical role in mediating these effects. Regular physical activity not only elevates BDNF levels but also fosters memory and learning, offering important implications for the prevention and treatment of neuropsychiatric and neurodegenerative conditions. Our findings underscore the necessity of incorporating exercise into a healthy lifestyle to optimize brain health. Future research is essential to elucidate the underlying mechanisms of this relationship and to refine exercise interventions for improved cognitive outcomes.
本综述研究了运动、脑源性神经营养因子（BDNF）、神经可塑性和认知功能之间的复杂关系，重点关注其对神经精神疾病和神经退行性疾病的影响。通过在各种数据库中搜索探索运动、BDNF、神经可塑性和认知健康之间联系的相关研究，进行了一项系统综述。对符合条件的研究分析表明，运动可提高大脑中的BDNF水平，促进神经可塑性并增强认知功能。此外，我们讨论了运动对认知衰退和神经系统疾病的保护作用，表明BDNF在介导这些作用中起关键作用。规律的体育活动不仅能提高BDNF水平，还能促进记忆和学习，对神经精神疾病和神经退行性疾病的预防和治疗具有重要意义。我们的研究结果强调了将运动纳入健康生活方式以优化大脑健康的必要性。未来的研究对于阐明这种关系的潜在机制以及改进运动干预措施以改善认知结果至关重要。
