An upgraded nuclease prime editor platform enables high-efficiency singled or multiplexed knock-in/knockout of genes in mouse and sheep zygotes.
作者信息
Mao Weijia, Wang Pei, Zhou Lei, Li Dongxu, Li Xiangyang, Lou Xin, Huang Xingxu, Wang Feng, Zhang Yanli, Liu Jianghuai, Wan Yongjie
机构信息
Livestock Embryo Engineering Laboratory, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center at Medical School of Nanjing University, Nanjing 210061, China.
出版信息
Protein Cell. 2025 Jan 20. doi: 10.1093/procel/pwaf006.
PMID:39832212
Abstract
摘要
Zotero 插件