Tan Teck H A, Johansson Helena, Harvey Nicholas C, Lorentzon Mattias, Kanis John A, McCloskey Eugene, Schini Marian
Fast and Chronic Programmes, Alexandra Hospital, Singapore.
Division of Endocrinology, Department of Medicine, National University Health System, Singapore.
Gac Med Mex. 2024;160(4):363-373. doi: 10.24875/GMM.24000107.
FRAX, a risk calculator that provides individualized 10-year probabilities of hip and major osteoporotic fracture, has been widely used for fracture risk assessment since its launch in 2008. It is now incorporated into very many guidelines worldwide to inform osteoporosis management. In this review, we explore the development of FRAX and how it enhances fracture risk prediction as compared to use of bone mineral density alone, as well as approaches to utilizing FRAX in determining intervention and assessment thresholds. We also discuss the limitations of FRAX and the arithmetic adjustments that have been proposed to address these. The introduction of FRAXplus includes these adjustments on a web-based platform for ease of application to enhance treatment decisions in osteoporosis.
FRAX是一种风险计算器，可提供个体发生髋部骨折和主要骨质疏松性骨折的10年概率，自2008年推出以来已广泛用于骨折风险评估。目前，它已被纳入全球众多指南，为骨质疏松症管理提供依据。在本综述中，我们探讨了FRAX的发展历程，以及与单独使用骨密度相比，它如何增强骨折风险预测，还探讨了在确定干预和评估阈值时使用FRAX的方法。我们还讨论了FRAX的局限性以及为解决这些局限性而提出的算术调整方法。FRAXplus的推出将这些调整整合到一个基于网络的平台上，便于应用，以改善骨质疏松症的治疗决策。
