Christison-Lagay Kate L, Khalaf Aya, Freedman Noah C, Micek Christopher, Kronemer Sharif I, Gusso Mariana M, Kim Lauren, Forman Sarit, Ding Julia, Aksen Mark, Abdel-Aty Ahmad, Kwon Hunki, Markowitz Noah, Yeagle Erin, Espinal Elizabeth, Herrero Jose, Bickel Stephan, Young James, Mehta Ashesh, Wu Kun, Gerrard Jason, Damisah Eyiyemisi, Spencer Dennis, Blumenfeld Hal
Department of Neurology, Yale University, New Haven, CT 06520, USA.
Department of Neurology, Yale University, New Haven, CT 06520, USA; Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520, USA.
Neuroimage. 2025 Mar;308:121041. doi: 10.1016/j.neuroimage.2025.121041. Epub 2025 Jan 19.
Although recent work has made headway in understanding the neural temporospatial dynamics of conscious perception, much of that work has focused on visual paradigms. To determine whether there are shared mechanisms for perceptual consciousness across sensory modalities, here we test within the auditory domain. Participants completed an auditory threshold task while undergoing intracranial electroencephalography. Recordings from >2,800 grey matter electrodes were analyzed for broadband gamma power (a range which reflects local neural activity). For perceived trials, we find nearly simultaneous activity in early auditory regions, the right caudal middle frontal gyrus, and the non-auditory thalamus; followed by a wave of activity that sweeps through auditory association regions into parietal and frontal cortices. For not perceived trials, significant activity is restricted to early auditory regions. These findings show the cortical and subcortical networks involved in auditory perception are similar to those observed with vision, suggesting shared mechanisms for conscious perception.
尽管最近的研究在理解有意识感知的神经时空动力学方面取得了进展，但其中大部分工作都集中在视觉范式上。为了确定跨感觉模态的感知意识是否存在共享机制，我们在此进行听觉领域的测试。参与者在接受颅内脑电图检查时完成了一项听觉阈值任务。对来自2800多个灰质电极的记录进行了宽带伽马功率分析（该范围反映局部神经活动）。对于被感知的试验，我们发现在早期听觉区域、右侧尾侧额中回和非听觉丘脑几乎同时出现活动；随后是一波活动，席卷听觉联合区域进入顶叶和额叶皮质。对于未被感知的试验，显著活动仅限于早期听觉区域。这些发现表明，参与听觉感知的皮质和皮质下网络与视觉观察到的网络相似，这表明有意识感知存在共享机制。
