Gerardo Heloísa, Oliveira Paulo J, Cavadas Cláudia, Grãos Mário, Teixeira José
CNC-UC, Center for Neuroscience and Cell Biology, University of Coimbra, Portugal; CIBB, Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
CNC-UC, Center for Neuroscience and Cell Biology, University of Coimbra, Portugal; CIBB, Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Portugal.
Biochim Biophys Acta Mol Basis Dis. 2025 Mar;1871(3):167678. doi: 10.1016/j.bbadis.2025.167678. Epub 2025 Jan 18.
Metabolic syndrome (MetS) has been associated with disruptions in tissue mechanical homeostasis and inflammatory and metabolic derangements. However, the direct correlation between metabolic alterations and changes in tissue stiffness, and whether they could play a role as upstream initiators of disease pathology remains to be investigated. This emerging concept has yet to be put into clinical practice as many questions concerning the interplay between extracellular matrix mechanical properties and regulation of metabolic pathways remain unsolved. This review will highlight key foundational studies examining mutual regulation of cell metabolism and mechanotransduction, and opening questions lying ahead for better understanding MetS pathophysiology.
代谢综合征（MetS）与组织机械稳态的破坏以及炎症和代谢紊乱有关。然而，代谢改变与组织硬度变化之间的直接关联，以及它们是否可能作为疾病病理的上游启动因素发挥作用，仍有待研究。由于许多关于细胞外基质机械特性与代谢途径调节之间相互作用的问题尚未解决，这一新兴概念尚未应用于临床实践。本综述将重点介绍关键的基础研究，这些研究探讨了细胞代谢与机械转导的相互调节，并提出了一些开放性问题，以便更好地理解代谢综合征的病理生理学。
