Marimuthu Sri Vidhya, Arul Devi, Santhanakrishnan Muthukumar, Elumalai Ramprasad, Suresh Sandhya, Selvarajan Sathya, Dhulipalla Ravindranath, Boyapati Ramanarayana
Department of Periodontology, Sri Ramachandra Dental College and Hospital, Chennai, India.
Department of Nephrology, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.
J Yeungnam Med Sci. 2025;42:22. doi: 10.12701/jyms.2025.42.22. Epub 2025 Jan 20.
Chronic periodontitis is associated with various systemic inflammatory diseases; however, research on its association with chronic kidney disease (CKD) is relatively limited. Because both conditions share common risk factors, systemic inflammation plays a key role in the progression of these diseases. Galectin-3 (Gal-3) is a proinflammatory cytokine that plays an important role in chronic inflammatory diseases and is a potential biomarker. This study aimed to measure salivary Gal-3 levels in patients with periodontitis and CKD to better understand their association and evaluate Gal-3 as a diagnostic biomarker for these conditions.
Seventy-five patients were categorized into three groups: Group I, patients with CKD and periodontitis (n=25); Group II, patients with chronic periodontitis who were systemically healthy (n=25); and Group III, patients with CKD without chronic periodontitis (n=25). Demographic characteristics and periodontal and renal parameters were recorded for each patient. Saliva samples were collected to evaluate Gal-3 levels using an enzyme-linked immunosorbent assay.
Patients with chronic periodontitis and CKD and those with chronic periodontitis alone (Groups I and II, respectively) showed significantly higher salivary Gal-3 levels than patients with CKD alone (Group III) (p<0.001). Bivariate correlation analysis indicated a strong relationship between clinical parameters and Gal-3 levels across all three groups.
Salivary Gal-3 level is a valuable early diagnostic marker of chronic periodontitis and CKD.
慢性牙周炎与多种全身性炎症性疾病相关；然而，关于其与慢性肾脏病（CKD）关联的研究相对有限。由于这两种疾病有共同的危险因素，全身性炎症在这些疾病的进展中起关键作用。半乳糖凝集素-3（Gal-3）是一种促炎细胞因子，在慢性炎症性疾病中起重要作用，是一种潜在的生物标志物。本研究旨在测量牙周炎和CKD患者的唾液Gal-3水平，以更好地了解它们之间的关联，并评估Gal-3作为这些疾病的诊断生物标志物。
75名患者被分为三组：第一组，患有CKD和牙周炎的患者（n = 25）；第二组，全身健康的慢性牙周炎患者（n = 25）；第三组，无慢性牙周炎的CKD患者（n = 25）。记录每名患者的人口统计学特征以及牙周和肾脏参数。收集唾液样本，使用酶联免疫吸附测定法评估Gal-3水平。
患有慢性牙周炎和CKD的患者以及仅患有慢性牙周炎的患者（分别为第一组和第二组）的唾液Gal-3水平显著高于仅患有CKD的患者（第三组）（p<0.001）。双变量相关性分析表明，所有三组的临床参数与Gal-3水平之间存在密切关系。
唾液Gal-3水平是慢性牙周炎和CKD的有价值的早期诊断标志物。
