Balajková Veronika, Prokopcová Aneta, Elisak Martin, Mojžišová Hana, Pavelka Karel, Olejárová Marta
Institute of Rheumatology, Prague 2, Czech Republic.
Department of Rheumatology, Charles University, Praha, Czech Republic.
Lupus Sci Med. 2025 Jan 19;12(1):e001309. doi: 10.1136/lupus-2024-001309.
The neurofilament light chain (NfL) in cerebrospinal fluid (CSF) and serum as a marker of neuronal damage may be a potential biomarker of neuropsychiatric involvement in SLE (NPSLE).
80 patients with SLE were included.We obtained paired serum and CSF samples from 48 patients (NPSLE n=32, non-NPSLE n=16) and 31 controls. The serum and CSF levels of NfL were determined using ELISA.
Patients with NPSLE demonstrated significantly higher levels of serum NfL compared with the non-NPSLE group (mean 31.68±36.63 pg/mL vs mean 16.75±12.48 pg/mL, respectively, p<0.05) and with controls (mean 10.74±4.36 pg/mL, p<0.01). Notably, CSF NfL concentrations in patients with NPSLE showed an upward trend (mean 1600±2852 pg/mL) in contrast to non-NPSLE patients (mean 393.4±191.9 pg/mL) and controls (mean 509.7±358.5 pg/mL). Furthermore, a positive correlation was observed between serum and CSF NfL levels in patients with NPSLE (R=0.8686, p<0.01). Elevated serum triacylglycerol concentrations, C reactive protein and organ damage were linked to increased serum (p=0.002; p<0.001; p=0.036) and CSF (p=0.008; p=0.007; p<0.001) NfL concentrations. In addition, we established a significant correlation between intrathecal NfL concentrations and interleukin-6 levels in the CSF of patients with NPSLE (R=0.5118, p<0.05).
The serum NfL levels may be a readily available marker of neuropsychiatric involvement in SLE.
脑脊液（CSF）和血清中的神经丝轻链（NfL）作为神经元损伤的标志物，可能是系统性红斑狼疮（SLE）神经精神受累的潜在生物标志物。
纳入80例SLE患者。我们从48例患者（神经精神性SLE患者32例，非神经精神性SLE患者16例）和31例对照中获取配对的血清和脑脊液样本。采用酶联免疫吸附测定法（ELISA）测定NfL的血清和脑脊液水平。
与非神经精神性SLE组相比，神经精神性SLE患者的血清NfL水平显著更高（分别为平均31.68±36.63 pg/mL和平均16.75±12.48 pg/mL，p<0.05），与对照组相比也显著更高（平均10.74±4.36 pg/mL，p<0.01）。值得注意的是，与非神经精神性SLE患者（平均393.4±191.9 pg/mL）和对照组（平均509.7±358.5 pg/mL）相比，神经精神性SLE患者的脑脊液NfL浓度呈上升趋势（平均1600±2852 pg/mL）。此外，在神经精神性SLE患者中，血清和脑脊液NfL水平之间存在正相关（R=0.8686，p<0.01）。血清甘油三酯浓度升高、C反应蛋白和器官损伤与血清（p=0.002；p<0.001；p=0.036）和脑脊液（p=0.008；p=0.007；p<0.001）NfL浓度升高有关。此外，我们在神经精神性SLE患者的脑脊液中发现鞘内NfL浓度与白细胞介素-6水平之间存在显著相关性（R=0.5118，p<0.05）。
血清NfL水平可能是SLE神经精神受累的一个易于获得的标志物。
