Al-Abboody Rafal Sameer, Heydari Nadia, Saravani Mohsen, Nosaratzehi Shahin, Akbari Hamideh, Jafari Seyyed Mehdi
Metabolic Disorders Research Center, 125691 Golestan University of Medical Sciences , Gorgan, Iran.
Department of Biochemistry and Biophysics, Faculty of Medicine, 125691 Golestan University of Medical Sciences , Gorgan, Iran.
J Basic Clin Physiol Pharmacol. 2025 Jan 21;36(1):61-67. doi: 10.1515/jbcpp-2024-0060. eCollection 2025 Jan 1.
Numerous studies show that the adipokines play a role in on the thyroid axis. The aim of this study was the evaluation of serum level of CTRP-3 and CTRP-6 as a member of the adipokines family in patients with Hashimoto's.
The levels of CTRP-3 and CTRP-6 were evaluated with enzyme-linked immunosorbent assay in 70 subjects (35 newly diagnosed Hashimoto's thyroiditis and 35 healthy subjects). Their relationship with the thyroid hormone and some biochemical factors was analyzed.
The levels of CTRP3 and CTRP6 in patients with Hashimoto's disease were higher than those in the control group (p<0.05). There was a significant positive correlation between CTRP3 and TSH levels (r=0.286 and p=0.017). There was a significant relationship between CTRP3 and Fasting Blood Sugar (r=0.249 and p=0.038). There was a significant inverse negative correlation between CTRP6 levels and T3 (r=-0.269 and p=0.024), and T4 (r=-0.272 and p=0.023). Moreover, there was a significant positive correlation between CTRP6 serum levels and TSH serum levels (r=0.397 and p=0.001). There was a significant positive correlation between CTRP6 levels and Cholesterol (r=0.351 and p=0.003), and LDL (r=-0.244 and p=0.042).
Finally, our results demonstrated that serum levels of CTRP3 and CTRP6 are higher in patients with Hashimoto's compared to the control group and probably play a role in the pathogenesis of Hashimoto's thyroiditis.
众多研究表明脂肪因子在甲状腺轴中发挥作用。本研究旨在评估作为脂肪因子家族成员的CTRP - 3和CTRP - 6在桥本氏病患者中的血清水平。
采用酶联免疫吸附测定法评估70名受试者（35名新诊断的桥本氏甲状腺炎患者和35名健康受试者）的CTRP - 3和CTRP - 6水平。分析它们与甲状腺激素及一些生化因子的关系。
桥本氏病患者的CTRP3和CTRP6水平高于对照组（p<0.05）。CTRP3与促甲状腺激素水平之间存在显著正相关（r = 0.286，p = 0.017）。CTRP3与空腹血糖之间存在显著关系（r = 0.249，p = 0.038）。CTRP6水平与T3（r = - 0.269，p = 0.024）和T4（r = - 0.272，p = 0.023）之间存在显著负相关。此外，CTRP6血清水平与促甲状腺激素血清水平之间存在显著正相关（r = 0.397，p = 0.
