Xiao Min, Ji Lei, Qian Xiaoyan, Chen Xi, Xiu Meng, Li Zhuoran, Cao Heng, Chen Shanshan, Li Qing, Li Qiao, Wang Xiang, Wang Jiani, Li Yiqun, Zheng Xiaojuan, Zhang Jintao, Zhang Pin
Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Medical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.
BMJ Open. 2025 Jan 20;15(1):e085842. doi: 10.1136/bmjopen-2024-085842.
The purpose of this study was to investigate the quality of life (QoL) of older Chinese patients with breast cancer and to explore further the associations of functions, symptoms, financial burdens and comorbidities with global health/quality of life (gQoL).
This was a cross-sectional study carried out following the Strengthening the Reporting of Observational Studies in Epidemiology checklist.
This study was conducted in two hospitals in Beijing from October 2021 to November 2022.
Patients with breast cancer aged over 65 years were included in the final analysis, which comprised a total of 481 patients.
The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and the Charlson Comorbidity Index (CCI) were used to assess patients' QoL and comorbidities. The data were analysed using network analysis and path analysis.
Out of the 136 possible edges in the final networks, 84 (61.8%) were non-zero. 'Fatigue' was the central symptom and indirectly decreased the gQoL, which was mediated by increasing 'financial difficulties', 'CCI' and 'role function' (β = -0.35, p<0.001). 'Physical function' was also an important and direct intervention node that was indirectly related to gQoL, and this was mediated by 'role function' (β = -0.15, p=0.006). Path analysis accounted for 32.0% of the total effect.
The various dimensions of QoL are highly interrelated and mutually reinforcing. These results highlight the importance of improving the fatigue and physical function of older patients with breast cancer. Interventions targeting these symptoms may lead to an overall improvement in gQoL.
ChiCTR2200056070; Public title: Frailty and Comorbidity in the Elderly Study (FACE Study).
本研究旨在调查中国老年乳腺癌患者的生活质量（QoL），并进一步探讨功能、症状、经济负担和合并症与总体健康/生活质量（gQoL）之间的关联。
这是一项横断面研究，按照加强流行病学观察性研究报告清单进行。
本研究于2021年10月至2022年11月在北京的两家医院进行。
最终分析纳入了65岁以上的乳腺癌患者，共481例。
使用欧洲癌症研究与治疗组织生活质量问卷核心30和查尔森合并症指数（CCI）来评估患者的生活质量和合并症。数据采用网络分析和路径分析进行分析。
在最终网络中的136条可能边中，84条（61.8%）非零。“疲劳”是核心症状，通过增加“经济困难”、“CCI”和“角色功能”间接降低gQoL（β = -0.35，p<0.001）。“身体功能”也是一个重要的直接干预节点，与gQoL间接相关，通过“角色功能”介导（β = -0.15，p = 0.006）。路径分析占总效应的32.0%。
生活质量的各个维度高度相关且相互促进。这些结果凸显了改善老年乳腺癌患者疲劳和身体功能的重要性。针对这些症状的干预可能会导致gQoL的整体改善。
ChiCTR2200056070；公开标题：老年人衰弱与合并症研究（FACE研究）。
