Department of Pharmacy Technology, Higher Institute of Medical Sciences and Technology, Bani Waleed, Libya.
Department of Pharmacy, Al Rafidain University College, Baghdad, Iraq.
Asian Pac J Cancer Prev. 2023 Mar 1;24(3):769-781. doi: 10.31557/APJCP.2023.24.3.769.
Fatigue is a typical consequence of cancer that can affect one's quality of life (QOL). The goal of this review is to provide comprehensive data on the impact of fatigue on QOL of cancer patients.
An electronic data search in Web of Science, SCOPUS, and PubMed for relevant papers; those written in English; those reporting quantitative data; and those including more than one hundred patients who received just chemotherapy were included. Studies involving participants that received other kinds of anti-neoplastic therapies were excluded.
A total of 35 papers published between January 2000 and December 2021 were retrieved from the search databases of which (11612 patients) met the inclusion criteria. Findings showed that fatigue negatively affected QOL with a pooled prevalence of 49% (95% CI; 25.00-74.00) and the significant heterogeneity between articles was (I²=98%, P <0.001). Further, breast cancer contributed to the majority of selected articles with about 55 % (95%CI; 9:00- 94:00), followed by cancer (unspecified) 44% (95%CI; 5:00 - 92:00). Most studies (71%) (95%CI; 4:00 - 99:00) used the brief fatigue inventory (BFI) tool to assess severity of fatigue and 39% (95%CI; 17:00 -68:00) employed the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire to evaluate QOL among cancer survivors.
The prevalence of fatigue in cancer patients is high and fatigue has a negative impact on QOL of cancer patients receiving chemotherapy. Directionality, fatigue needs to be addressed and treated properly for better improvement of health status and QOL in cancer patients.
疲劳是癌症的一种典型后果，会影响患者的生活质量（QOL）。本综述的目的是提供关于疲劳对癌症患者 QOL 影响的全面数据。
在 Web of Science、SCOPUS 和 PubMed 中进行电子数据检索，检索相关文献；文献为英文；报告定量数据；纳入接受单纯化疗的患者超过 100 例。排除纳入接受其他抗肿瘤治疗的患者的研究。
从检索数据库中检索到 2000 年 1 月至 2021 年 12 月期间发表的 35 篇论文，其中（11612 例患者）符合纳入标准。研究结果表明，疲劳对 QOL 有负面影响，总患病率为 49%（95%CI；25.00-74.00），且文章间存在显著异质性（I²=98%，P <0.001）。此外，乳腺癌占所选文章的大部分，约 55%（95%CI；9：00-94：00），其次是癌症（未特指）44%（95%CI；5：00-92：00）。大多数研究（71%）（95%CI；4：00-99：00）使用简短疲劳量表（BFI）工具评估疲劳严重程度，39%（95%CI；17：00-68：00）使用欧洲癌症研究与治疗组织生活质量问卷评估癌症幸存者的 QOL。
癌症患者疲劳的发生率较高，疲劳对接受化疗的癌症患者的 QOL 有负面影响。需要关注并正确处理疲劳的方向性，以改善癌症患者的健康状况和 QOL。
