Zhang Yuping, Chen Yueqing, Li Chen
Department of Dermatology, Zhongshan City People's Hospital, Zhongshan, Guangdong, China.
Guangdong Medical University, Zhanjiang, Guangdong, China.
Medicine (Baltimore). 2025 Jan 17;104(3):e41277. doi: 10.1097/MD.0000000000041277.
This study evaluates the efficacy and safety of soothing moisturizing repairing cream combined with desonide in the treatment of atopic dermatitis (AD) in children in the real world. A total of 37 children with AD were randomly divided into experimental (17) and control (20) groups. For the experimental group, treated with moisturizing cream combined with desonide cream, the maintenance period was with moisturizer alone. For the control group, treated solely with desonide, the maintenance period was with nothing. Clinical assessments were made before and 1, 2, and 4 weeks after treatment. Efficacy indicators are compared between the 2 groups, and the relieving effect of moisturizer on the maintenance period of AD in children is observed. Adverse reactions are also recorded. After 4 weeks of treatment, the cure rate and effectiveness rate in the experimental group were 52.9% and 100%, respectively, compared to 0% and 60% in the control group; the estimated median maintenance time was 48 days for the control group and 73 days for the experimental group. The incidence of adverse reactions shows no statistical significance. The combination of moisturizing cream and desonide in the treatment of AD in children is highly effective and safe. It is worth promoting for clinical application due to its significant therapeutic effects and high safety profile.
本研究在现实世界中评估舒缓保湿修复霜联合地奈德治疗儿童特应性皮炎（AD）的疗效和安全性。共37例AD患儿被随机分为试验组（17例）和对照组（20例）。试验组采用保湿霜联合地奈德乳膏治疗，维持期仅使用保湿剂。对照组仅用地奈德治疗，维持期不使用任何药物。在治疗前以及治疗后1、2和4周进行临床评估。比较两组的疗效指标，观察保湿剂对儿童AD维持期的缓解作用。同时记录不良反应。治疗4周后，试验组的治愈率和有效率分别为52.9%和100%，而对照组分别为0%和60%；对照组的估计中位维持时间为48天，试验组为73天。不良反应发生率无统计学意义。保湿霜与地奈德联合治疗儿童AD高效且安全。因其显著的治疗效果和高安全性，值得在临床应用中推广。
