Wei Shubin, Cui Xinyi, Li Tingting, Ma Xin, Liu Luzhi
School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, Guangxi, P. R. China.
Guangxi Key Laboratory of Green Chemical Materials and Safety Technology, Guangxi Engineering Research Center for New Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou, Guangxi, 535011, PR China.
ChemMedChem. 2025 Apr 1;20(7):e202400822. doi: 10.1002/cmdc.202400822. Epub 2025 Jan 20.
Macrocyclic supramolecular materials play an important role in encapsulating anticancer drugs to improve the anticancer efficiency and reduce the toxicity to normal tissues through host-guest interactions. Among them, pillar[n]arenes, as an emerging class of supramolecular macrocyclic compounds, have attracted increasing attention in drug delivery and drug-controlled release due to their high biocompatibility, excellent host-guest chemistry, and simplicity of modification. In this review, we summarize the research progress of pillar[n]arene-based supramolecular nanodrug delivery systems (SNDs) in recent years in the field of tumor therapy, including drug-controlled release, imaging diagnostics and therapeutic modalities. Furthermore, the opportunities and major limitations of pillar[n]arene-based SNDs for tumor therapy are discussed.
大环超分子材料在通过主客体相互作用封装抗癌药物以提高抗癌效率并降低对正常组织的毒性方面发挥着重要作用。其中，柱芳烃作为一类新兴的超分子大环化合物，因其高生物相容性、优异的主客体化学性质和修饰的简便性，在药物递送和药物控释方面受到越来越多的关注。在本综述中，我们总结了近年来基于柱芳烃的超分子纳米药物递送系统（SNDs）在肿瘤治疗领域的研究进展，包括药物控释、成像诊断和治疗方式。此外，还讨论了基于柱芳烃的SNDs在肿瘤治疗中的机遇和主要局限性。
